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Role of Monoamine Oxidase A Genotype and Psychosocial Factors in Male Adolescent Criminal Activity
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
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2006 (English)In: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 2, no 59, 121-127 p.Article in journal (Refereed) Published
Abstract [en]

Background

A number of important sociological, psychological, and biological predictors of adolescent criminal behavior have been identified during the most recent decades. The aim of this study was to replicate recent findings that interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter region and psychosocial factors might predict male adolescent criminal activity.

Methods

A cross-sectional study with a randomized sample from the total population of 16- and 19-year-olds from the county of Västmanland, Sweden. Eighty-one male adolescents, who volunteered to participate, were randomly selected from groups representing different degrees of deviant risk behavior.

Results

The present study strongly supports the notion that carrying the 3-repeat allele of the MAO-A–gene promoter increases the risk of male adolescent criminal behavior, when interacting with psychosocial factors. No effects at all of the MAO-A genotype on adolescent criminal activity were found when MAO-A genotype was considered alone (i.e., without its psychosocial context). The explained variance of the bio-psychosocial model (controlling for MAO-A) in this study exceeded the psychosocial model by 12%.

Conclusions

The findings support the notion that genotype and psychosocial factors interact to precipitate male adolescent criminal behavior.

Place, publisher, year, edition, pages
2006. Vol. 2, no 59, 121-127 p.
Keyword [en]
adolescents, criminology, genes, social support, environment, linear models
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-94071DOI: 10.1016/j.biopsych.2005.06.024ISI: 000234871600004OAI: oai:DiVA.org:uu-94071DiVA: diva2:167795
Available from: 2006-03-17 Created: 2006-03-17 Last updated: 2012-08-22Bibliographically approved
In thesis
1. Gene-Environment Interaction in Adolescent Deviant Behaviour
Open this publication in new window or tab >>Gene-Environment Interaction in Adolescent Deviant Behaviour
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The overall aim of this thesis was to explore gene-environmental (G*E) interactions in relation to deviant behaviour among 200 Swedish adolescents, with a focus on criminality, alcohol consumption and depressive symptoms. Those behaviours have been extensively investigated in relation to both psychosocial and biological risk factors. The biological markers used were the monoamine oxidase (MAO-A) and serotonin transporter (5-HTTLPR) gene polymorphisms.

The main findings indicated a considerable gene-environment interaction in relation to all outcome variables studied. Individuals with the long/short variant of the 5HTTLPR gene, in combination with unfavourable family relations, both consumed more alcohol and had 12-14 times higher risks of being classified as high alcohol consumers.

The MAO-A gene showed a G*E interaction related to criminality. Among boys, the short allele predicted an increased risk for criminality, whereas among girls, it was the long allele, if they lived in multi-family houses and/or had been maltreated, assaulted or sexually abused.

A G*E interaction in relation to depressive symptoms among both boys and girls was determined. Girls carrying the short 5HTTLPR allele in combination with psychosocial stress, presented elevated depressive symptoms, whereas among boys, the long 5HTTLPR allele was a source of depressive symptoms. In both sexes, there was a G*E interaction of a psychosocial risk index. Girls were more affected by poor family relations and boys by multi-family housing and separated parents.

In conclusion, the MAO-A and 5HTTLPR genotypes, in interaction with psychosocial adversity, are related to different deviant behaviours among adolescents. The direct effects of the genotypes needed to be adjusted for the psychosocial factors, whereas the psychosocial factors had direct relation to the outcome measures. There is also an indication of a different pattern in G*E interaction between boys and girls and that different psychosocial factors affect boys and girls differently.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2006. 91 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 114
Keyword
Neurobiology, Adolescent, Alcohol, Criminology, Genes, Environment, Monoamine Oxidase, Serotonin, Social Support, Neurobiologi
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-6536 (URN)91-554-6478-5 (ISBN)
Public defence
2006-04-07, Kongresshallen, AROS CONGRESS CENTER, Munkgatan 7, Västerås, 13:15
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Available from: 2006-03-17 Created: 2006-03-17 Last updated: 2011-02-10Bibliographically approved

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Nillson, Kent W.Sjöberg, Rickard L.Leppert, JerzyLindström, LeifOreland, Lars

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