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Biochemical indicators of cardiac and renal function in a healthy elderly population
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
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2004 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 37, no 3, 210-216 p.Article in journal (Refereed) Published
Abstract [en]

Objectives:

To examine the distributions of NT-proBNP and cystatin C and their relation to age, gender, and other physiological factors in an apparently healthy elderly population.

Method:

NT-proBNP and cystatin C were analyzed in 407 and 408 healthy individuals, median age: 65 (range 40–76).

Results:

Increasing age, female gender and CRP were independently associated to higher NT-proBNP levels. Age, body mass index, and CRP level were independently associated to the cystatin C level. In women and men, ≤65 years, the 97.5th percentile value for NT-proBNP was 268 ng/l and 184 ng/l, in those older, 391 ng/l and 269 ng/l. For those ≤65 years the 97.5th percentile value for cystatin C was 1.12 mg/l, and for those older 1.21 mg/l.

Conclusion:

In a healthy elderly population, NT-proBNP is influenced by age and gender, whereas cystatin C is influenced by age but not by gender. Both markers seem to be associated to the CRP level.

Place, publisher, year, edition, pages
2004. Vol. 37, no 3, 210-216 p.
Keyword [en]
NT-proBNP, Cystatin C, Cardiac and renal function, Healthy elderly population
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-94119DOI: 10.1016/j.clinbiochem.2003.11.002PubMedID: 14972643OAI: oai:DiVA.org:uu-94119DiVA: diva2:167864
Available from: 2006-03-17 Created: 2006-03-17 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Low-Density Lipoprotein Oxidation and Renal Dysfunction: New Markers of Poor Prognosis in Patients with Unstable Coronary Artery Disease
Open this publication in new window or tab >>Low-Density Lipoprotein Oxidation and Renal Dysfunction: New Markers of Poor Prognosis in Patients with Unstable Coronary Artery Disease
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In patients with unstable coronary artery disease (CAD) biochemical markers are emerging as useful tools in clinical management. In this thesis we studied the use of markers of low-density lipoprotein (LDL) oxidation and renal function.

Our study populations consisted of unstable CAD patients included in the Fast Revascularisation during Instability in Coronary artery disease (FRISC)-II trial and healthy controls. Patients were followed for 2 years regarding death and myocardial infarction (MI).

Using receiver operating characteristic curve analysis, we found that oxidized low-density lipoprotein (OxLDL), especially when combined with high-density lipoprotein, compared to traditionally measured lipids/lipoproteins, and a new lipoprotein marker, lipoprotein associated-phospholipase A2, was better at discriminating between healthy controls and CAD patients. In patients, OxLDL was found to be an independent prognostic marker associated with an increased risk of MI, of particular use in patients with no evidence of myocardial necrosis.

In our study on the effects of an early invasive treatment strategy in unstable CAD patients with mild to moderate renal dysfunction (i.e. creatinine clearance <90mL/min) we found that in patients randomized to invasive treatment, the rates of death/MI and MI alone were significantly lower than in patients randomized to non-invasive treatment. In patients treated invasively, no detrimental effects were seen on renal function at follow-up at 6 months.

In healthy controls, we investigated new markers of renal (cystatin C) and cardio-renal function (N-terminal probrain natriuretic peptide, [NT-proBNP]) regarding reference levels and physiological determinants. We found that cystatin C is influenced by age whereas NT-proBNP is influenced by age and gender.

Our studies suggest that OxLDL and renal dysfunction are associated with a poor prognosis in unstable CAD patients and that these markers demonstrate potential for clinical use. In the search for new markers related to renal function we have contributed with reference levels of cystatin C and NT-proBNP.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2006. 64 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 120
Keyword
Medicine, myocardial infarction, unstable angina, oxidized low-density lipoprotein, renal function, prognosis, Medicin
National Category
Dermatology and Venereal Diseases
Identifiers
urn:nbn:se:uu:diva-6626 (URN)91-554-6488-2 (ISBN)
Public defence
2006-04-07, Ebba Enghoffssalen, Akademiska sjukhuset, ingång 50, Uppsala, 09:15
Opponent
Supervisors
Available from: 2006-03-17 Created: 2006-03-17Bibliographically approved

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Johnston, NinaLindahl, BertilLindbäck, JohanStridsberg, MatsLarsson, AndersVenge, PerWallentin, Lars

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