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Biodegradable Ionomers
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
2006 (English)In: Macromolecules, ISSN 0024-9297, E-ISSN 1520-5835, Vol. 39, no 11, 3907-3913 p.Article in journal (Refereed) Published
Abstract [en]

Several telechelic anionic or cationic ionomers were synthesized starting from poly(trimethylene carbonate) diols (PTMC) of different molecular weight, ranging from 1000 to 12 000 g/mol. In the synthesis of the anionomer, addition of sulfur trioxide trimethylene complex to the PTMC end-group hydroxyls and subsequent ion exchange afforded a disulfate monoester sodium salt. The cationomer was synthesized in two steps. Acylation of the PTMC diol using 4-chlorobuturyl chloride was followed by displacement of the alkyl chloride with trimethylamine to give a quaternary ammonium salt. These ionomers showed excellent swelling properties, up to around 500% in H2O, while the unfunctionlized PTMC did not swell at all. The lowest molecular weight ionomers were soluble in both water and chloroform. The physical properties of the ionomers were analyzed with oscillating rheological experiments. Interestingly, the ionomers displayed "rubbery plateau". The mechanical and swelling properties may be linked to phase separation resulting in ionic aggregates within the bulk, which may function as physical cross-links. At ambient temperatures, the PTMC starting material behaved like a highly viscous fluid, while the ionomers behaved as elastomers. In a hydrophilic environment, the ionomers displayed a surface rearrangement making the surface of the ionomer hydrophilic by allowing the ionic end groups to appear at the water ionomer interface. In air or vacuum all the ionic groups were found in the bulk of the material as analyzed by XPS or contact angle measurements. Finally, we showed that with the specific ionic groups it was possible to complex specific molecules to the ionomers.

Place, publisher, year, edition, pages
2006. Vol. 39, no 11, 3907-3913 p.
National Category
Inorganic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-94594DOI: 10.1021/ma0603783OAI: oai:DiVA.org:uu-94594DiVA: diva2:168490
Available from: 2006-05-17 Created: 2006-05-17 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Tailoring of Biomaterials using Ionic Interactions: Synthesis, Characterization and Application
Open this publication in new window or tab >>Tailoring of Biomaterials using Ionic Interactions: Synthesis, Characterization and Application
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The interactions between polymers and components of biological systems are an important area of interest within the fields of tissue engineering, polymer chemistry, medicine and biomaterials. In order to create such a biomimetic material, it must show the inherent ability to reproduce or elicit a biological function. How do we design synthetic materials in order to direct their interactions with biological systems?

This thesis contributes to this research with aspects of how polymers interact with biological materials with the help of ionic interactions. Polyesters, biodegradable or not, may after a hydrolytic cleavage interact ionically with protonated amines by the liberated carboxylate functions. Amines are found in proteins and this fact will help us to anchor proteins to polyester surfaces. Another type of interaction is to culture cells in polymeric materials, i.e. scaffolds. We have been working on compliant substrates, knitted structures, to allow cell culture in three dimensions. A problem that arises here is how to get a high cell seeding efficiency? By working on the interactions between polymers, proteins and finally cells, it is possible to create a polarized protein membrane that allows for very efficient cell seeding, and subsequent three dimensional cell cultures. Finally a synthetic route to taylor interaction was developed. Here a group of polymers known as ionomers were synthesized. In our case ionic end groups have been placed onto biodegradable polycarbonates, we have created amphiphilic telechelic ionomers. Functionalization, anionic or cationic, changes the properties of the material in many ways due to aggregation and surface enrichment of ionic groups. It is possible to add functional groups for a variety of different interactions, for example introducing ionic groups that interact and bind to the complementary charge of proteins or on the other hand one can chose groups to prevent protein interactions, like the phosphorylcholine zwitterionomers. Such interactions can be utilized to modulate the release of proteins from these materials when used in protein delivery applications. The swelling properties, Tg, degradation rate and mechanical properties are among other things that will easily be altered with the choice of functional groups or backbone polymer.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2006. 92 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 193
Keyword
Chemistry, biodegradable polymers, ionomer, water uptake, protein delivery, protein adsorption, protein membrane, cell seeding efficiency, amphiphillic, inner structure, polarized membrane, Kemi
Identifiers
urn:nbn:se:uu:diva-6924 (URN)91-554-6585-4 (ISBN)
Public defence
2006-06-07, Polhemsalen, Ångströmlaboratoriet, Regementsvägen 1, Uppsala, 10:00
Opponent
Supervisors
Available from: 2006-05-17 Created: 2006-05-17 Last updated: 2013-09-26Bibliographically approved

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