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Simultaneous Measurement of Drug Release and Liquid Uptake in Pharmaceutical Tablets
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science.ORCID iD: 0000-0002-5496-9664
2003 (English)In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 92, no 6, 1242-1249 p.Article in journal (Refereed) Published
Abstract [en]

A new method is introduced that allows drug release and liquid absorption to be studied simultaneously. The drug release is measured by the alternating ionic current (AIC) method, and the study of liquid uptake is accomplished with a sensitive microbalance from a processor tensiometer. We show that the method can be employed to study anomalous diffusion in the initial phase of the drug release process of disintegrating systems. We also demonstrate that the diffusion layer thickness and the diffusion coefficient in a dissolving system can be obtained with the new measurement technique.

Place, publisher, year, edition, pages
2003. Vol. 92, no 6, 1242-1249 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-94616DOI: 10.1002/jps.10365OAI: oai:DiVA.org:uu-94616DiVA: diva2:168521
Available from: 2006-05-09 Created: 2006-05-09 Last updated: 2016-11-30Bibliographically approved
In thesis
1. Electrodynamic and Mechanical Spectroscopy Method Development and Analysis Relating to Materials with Biotechnological Applications
Open this publication in new window or tab >>Electrodynamic and Mechanical Spectroscopy Method Development and Analysis Relating to Materials with Biotechnological Applications
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Materials with biotechnological applications and materials that interact with the biological environment play an ever increasing role in our lives and society. In order to be able to tailor specific properties of these materials to suit their intended applications, it is important to gain a deeper understanding of the relationship between the material structure and its function.

This thesis contributes to the goal of achieving a better understanding of the functional properties of materials through the development of novel characterizing methods as well as the analysis of such materials. Electrodynamic and mechanical spectroscopy methods are developed or employed in the characterization of three classes of materials, namely, pharmaceutical, biomedical and biological materials.

Two electrodynamic methods utilizing conductivity measurements were developed for the investigation of drug release from pharmaceutical dosage forms, particularly in low liquid volumes. Furthermore, a mechanical spectroscopy method based on the split Hopkinson pressure bar setup was developed for the viscoelastic characterization of pharmaceutical compacts. It was shown that this method is a valuable complement to other methods of characterization.

Dielectric spectroscopy was integrated with microfabrication techniques to create a method for bacteria detection in a biotechnological application. As well, dielectric spectroscopy was used in the characterization of a novel biomimetic ionomer and was demonstrated to be a powerful tool for studying the bulk molecular dynamics of this functional material.

The work presented in this thesis not only provides an enhanced understanding of materials and their functional properties, but also presents new methods that should be useful for the future characterization of such materials.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2006. 71 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 196
Keyword
Engineering physics, Teknisk fysik
Identifiers
urn:nbn:se:uu:diva-6932 (URN)91-554-6591-9 (ISBN)
Public defence
2006-05-30, Häggsalen, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 09:30 (English)
Opponent
Supervisors
Available from: 2006-05-09 Created: 2006-05-09 Last updated: 2010-04-19Bibliographically approved

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Welch, KenStrömme, Maria

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