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Molecular dynamics of a biodegradable biomimetic ionomer studied by broadband dielectric spectroscopy
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry.
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2007 (English)In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 23, no 20, 10209-10215 p.Article in journal (Refereed) Published
Abstract [en]

Broadband dielectric spectroscopy was used to investigate the bulk molecular dynamics of a recently developed biodegradable biomimetic ionomer potentially useful for biomedical applications. Isothermal dielectric spectra were gathered for a phosphoryl choline (PC)-functionalized poly(trimethylene carbonate) (PTMC) ionomer and unfunctionalized PTMC at temperatures ranging from 2 to 60 degrees C over a broad frequency range of 10(-3) to 10(6) Hz. Four relaxations were clearly identified, two of which were shown to stem from the PTMC polymer backbone. A detailed analysis showed that the formation of zwitterionic aggregates was responsible for the material's bulk functionality and that bulk conduction processes may provide useful information for assessing the PC ionomer as a candidate for drug delivery applications. Finally, it was concludedthat absorbed water concentrates around the aggregates, resulting in an increased mobility of the PC end-groups.

Place, publisher, year, edition, pages
2007. Vol. 23, no 20, 10209-10215 p.
National Category
Natural Sciences Engineering and Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
URN: urn:nbn:se:uu:diva-94619DOI: 10.1021/la7009012ISI: 000249560100039OAI: oai:DiVA.org:uu-94619DiVA: diva2:168524
Available from: 2006-05-09 Created: 2006-05-09 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Electrodynamic and Mechanical Spectroscopy Method Development and Analysis Relating to Materials with Biotechnological Applications
Open this publication in new window or tab >>Electrodynamic and Mechanical Spectroscopy Method Development and Analysis Relating to Materials with Biotechnological Applications
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Materials with biotechnological applications and materials that interact with the biological environment play an ever increasing role in our lives and society. In order to be able to tailor specific properties of these materials to suit their intended applications, it is important to gain a deeper understanding of the relationship between the material structure and its function.

This thesis contributes to the goal of achieving a better understanding of the functional properties of materials through the development of novel characterizing methods as well as the analysis of such materials. Electrodynamic and mechanical spectroscopy methods are developed or employed in the characterization of three classes of materials, namely, pharmaceutical, biomedical and biological materials.

Two electrodynamic methods utilizing conductivity measurements were developed for the investigation of drug release from pharmaceutical dosage forms, particularly in low liquid volumes. Furthermore, a mechanical spectroscopy method based on the split Hopkinson pressure bar setup was developed for the viscoelastic characterization of pharmaceutical compacts. It was shown that this method is a valuable complement to other methods of characterization.

Dielectric spectroscopy was integrated with microfabrication techniques to create a method for bacteria detection in a biotechnological application. As well, dielectric spectroscopy was used in the characterization of a novel biomimetic ionomer and was demonstrated to be a powerful tool for studying the bulk molecular dynamics of this functional material.

The work presented in this thesis not only provides an enhanced understanding of materials and their functional properties, but also presents new methods that should be useful for the future characterization of such materials.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2006. 71 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 196
Keyword
Engineering physics, Teknisk fysik
Identifiers
urn:nbn:se:uu:diva-6932 (URN)91-554-6591-9 (ISBN)
Public defence
2006-05-30, Häggsalen, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 09:30 (English)
Opponent
Supervisors
Available from: 2006-05-09 Created: 2006-05-09 Last updated: 2010-04-19Bibliographically approved

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Welch, KenStrömme, Maria

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