Bilayer disk capillary electrophoresis: a novel method to study drug partitioning into membranes
2008 (English)In: Electrophoresis, ISSN 0173-0835, E-ISSN 1522-2683, Vol. 29, no 16, 3377-3383 p.Article in journal (Refereed) Published
CE in the presence of lipid bilayer disks was introduced as a new approach in membrane partitioning studies. The disks were used as a pseudostationary phase in the partial-filling mode of CE and the partitioning of cationic drugs was determined. The migration times of the analytes increased linearly with the lipid amount in the system. An appropriate algorithm for the calculation of a partition coefficient is presented. In the disk-shaped bilayers, which have excellent stability and shelf life, all of the lipids are readily available for interaction and the disks can be used as realistic cell membrane models.
Place, publisher, year, edition, pages
2008. Vol. 29, no 16, 3377-3383 p.
bilayer disks, capillary electrophoresis, drugs, model membrane, partitioning
IdentifiersURN: urn:nbn:se:uu:diva-94751DOI: 10.1002/elps.200700682ISI: 000258856900012PubMedID: 18702061OAI: oai:DiVA.org:uu-94751DiVA: diva2:168718