[C-11]methyl iodide from [C-11]methane and iodine using a non-thermal plasma method
2006 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 49, no 13, 1177-1186 p.Article in journal (Refereed) Published
A method and an apparatus for preparing [C-11]methyl iodide from [C-11]methane and iodine in a single pass through a non-thermal plasma reactor has been developed. The plasma was created by applying high voltage (400 V/31 kHz) to electrodes in a stream of helium gas at reduced pressure. The [C-11]methane used in the experiments was produced from [C-11]carbon dioxide via reduction with hydrogen over nickel. [C-11]methyl iodide was obtained with a specific radioactivity of 412 +/- 32 GBq/mu mol within 6 min from approximately 24 GBq of [C-11]carbon dioxide. The decay corrected radiochemical yield was 13 +/- 3% based on [C-11]carbon dioxide at start of synthesis. [C-11]Flumazenil was synthesized via a N-alkylation with the prepared [C-11]methyl iodide.
Place, publisher, year, edition, pages
2006. Vol. 49, no 13, 1177-1186 p.
[C-11]methyl iodide, [C-11]methane, non-thermal plasma, specific radioactivity
IdentifiersURN: urn:nbn:se:uu:diva-94929DOI: 10.1002/jlcr.1135ISI: 000242796700006OAI: oai:DiVA.org:uu-94929DiVA: diva2:168954