A base-stable dithiomethyl linker for solid-phase synthesis of oligonucleotides
2007 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 48, no 3, 469-472 p.Article in journal (Refereed) Published
A novel linkage, useful for the synthesis of oligonucleotides is described. The linking function is compatible with all conditions used for oligonucleotide synthesis, orthogonal to all other protecting groups, but regenerates 3′-OH rapidly upon mild reduction under aqueous conditions. This method is employed in the removal of depurinated fragments during the synthesis of oligonucleotides.
Place, publisher, year, edition, pages
2007. Vol. 48, no 3, 469-472 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-94936DOI: 10.1016/j.tetlet.2006.11.045ISI: 000243819100031OAI: oai:DiVA.org:uu-94936DiVA: diva2:168962