The tablet tensile strength (σt) is a tablet property that is evaluated during early drug development to ensure sufficient strength of the tablets, which can be described using the strength compaction-pressure relationship (SPR). Due to the limited amount of active component available at this point in time, it would be beneficial to be able to predicted the σt. The objective was therefore to evaluate the applicability of an earlier described hybrid approach to predict the SPR for binary powder mixtures consisting of sodium chloride and lactose monohydrate. This model describes the SPR in three stages based on the Kawakita parameter b-1, in-die Heckel yield stress and a parameter proportionality factor (α). Compared to the experimentally derived SPR profile, it was found that the SPR profile could be predicted satisfactorily using the hybrid approach. However, there was not one value for α that was universally applicable for all mixtures. Another approach explored to predict the SPR profile used the power law mixing rule to obtain mixture data based on single component data. It was found that predictions were better for mixtures with lower fraction of sodium chloride. Moreover, mixture based predictions were superior to those based on single component data.