uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Intracerebral microdialysis and intracranial compliance monitoring of patients with traumatic brain injury.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
Show others and affiliations
2006 In: J Clin Monit and Comput., Vol. 20, no 1, 25-31 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2006. Vol. 20, no 1, 25-31 p.
URN: urn:nbn:se:uu:diva-95054OAI: oai:DiVA.org:uu-95054DiVA: diva2:169117
Available from: 2006-11-06 Created: 2006-11-06Bibliographically approved
In thesis
1. Intracranial Compliance and Secondary Brain Damage. Experimental and Clinical Studies in Traumatic Head Injury
Open this publication in new window or tab >>Intracranial Compliance and Secondary Brain Damage. Experimental and Clinical Studies in Traumatic Head Injury
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Traumatic brain injury (TBI) renders the brain more vulnerable to secondary insults. The increased vulnerability can probably be explained by a combination of disturbances in hemodynamics, metabolism and craniospinal dynamics. Reduced ability to compensate for added intracranial volume, i.e. reduced intracranial compliance (IC), is one possible mechanism. The aim of this thesis was to study the role of IC on the effect of secondary insults after TBI.

A rat TBI model was developed where IC could be altered without causing pathological increases in intracranial pressure (ICP). Reduction of IC was made by placing rubber film between the dura mater and bilateral bone flaps. A reduction of IC in terms of reduced Pressure Volume Index was confirmed. Microdialysis (MD) of extracellular fluid was used to monitor neurochemical changes. Reduced IC after TBI proved to increase the vulnerability of the brain to secondary intracranial volume insults according to neurochemical microdialysis markers. Reduced IC or intracranial volume insults alone did not cause any metabolic changes as compared to controls. Moderate posttraumatic hypotension (50mmHg for 30 min) induced 2 hrs after TBI, did not aggravate posttraumatic extracellular neurochemical changes significantly, irrespective of the level of IC. Although controversial, a mild to moderate hypotensive insult after initial posttraumatic stabilization may not be as detrimental as earlier believed.

The Spiegelberg Compliance Monitor and MD were simultaneously used in 10 TBI patients to get an impression of the clinical value of IC monitoring and the relationship between IC, temperature and MD Lactate/Pyruvate ratio. IC and MD could be monitored simultaneously in TBI patients. Higher L/P ratios were seen when IC was low. Patients with induced coma treatment had significantly higher average L/P ratios, possibly due to their poorer neurological condition. An indication was also found that in TBI patients with high temperatures, L/P ratio rose as IC decreased, but in patients with low temperature there was no effect of IC on L/P ratio. These data suggest the importance of avoiding hyperthermia in TBI patients, especially in patients with low or decreased IC (monitored or anticipated).

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2006. 70 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 191
Neurosciences, Traumatic brain injury, Intracranial compliance, Secondary insults, Microdialysis, Neurointensive care, Neurovetenskap
urn:nbn:se:uu:diva-7214 (URN)91-554-6698-2 (ISBN)
Public defence
2006-11-24, Grönvallsalen, ingång 70, Akademiska sjukhuset, Uppsala, 13:15
Available from: 2006-11-06 Created: 2006-11-06Bibliographically approved

Open Access in DiVA

No full text

By organisation
Department of Neuroscience

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 142 hits
ReferencesLink to record
Permanent link

Direct link