Adenovirus-induced alterations in host cell gene expression prior to the onset of viral gene expression
2006 (English)In: Virology, ISSN 0042-6822, E-ISSN 1096-0341, Vol. 353, no 1, 1-5 p.Article in journal (Refereed) Published
In this report, we have studied gene expression profiles in human primary lung fibroblasts (IMR-90) during the very early phase of an adenovirus infection. Eight out of twelve genes with known functions encoded transcription factors linked to two major cellular processes; inhibition of cell growth (ATF3, ATF4, KLF4, KLF6 and ELK3) and immune response (NR4A1 and CEBPB), indicating that the earliest consequences of an adenovirus infection are growth arrest and induction of an immune response. A time course analysis showed that the induction of these immediate-early response genes was transient and suppressed after the onset of the adenovirus early gene expression.
Place, publisher, year, edition, pages
2006. Vol. 353, no 1, 1-5 p.
adenovirus, microarray, immediate response, gene expression
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-95072DOI: 10.1016/j.virol.2006.06.019ISI: 000240512100001PubMedID: 16860366OAI: oai:DiVA.org:uu-95072DiVA: diva2:169142