Adherence to treatment in Swedish HIV infected patients
2006 (English)In: Journal of Clinical Pharmacy and Therapeutics, ISSN 0269-4727, E-ISSN 1365-2710, Vol. 31, no 6, 605-616 p.Article in journal (Refereed) Published
Objectives: The objectives were to assess the prevalence of adherence to antiretroviral treatment in Swedish human immunodeficiency virus (HIV)-infected patients and to evaluate factors associated with adherence.
Methods: All HIV-treated patients, who attended one of 30 (of a total of 32) Swedish infectious diseases clinics, during 7 months, were asked to complete an anonymous questionnaire containing the 9-item Morisky Medication Adherence Scale (MMAS) and questions about other factors potentially affecting adherence. The summary score of MMAS ranges from 1 to 13, where 13 indicates perfect adherence; patients scoring 11 or above (corresponding to 95% adherence level) were classified as 'adherent'.
Results and discussion: In total 946 patients participated (response rate 97.5%). The proportion of patients who reported not missing a dose during the day prior to the completion of the questionnaire was 97% and the proportion classified as 'adherent' was 63%. 'Adherent' patients were more likely to have a good relationship with their health care professionals (P < 0.05) and not have problems with drugs or alcohol (P < 0.01). Being older (P < 0.01) and having a shorter time on current treatment (P < 0.01) and on treatment in total (P < 0.05) were factors also associated with good adherence.
Conclusion: Factors modifiable for interventions by health care professionals are patient-provider relationship, drug or alcohol problems and patients with long treatment periods.
Place, publisher, year, edition, pages
2006. Vol. 31, no 6, 605-616 p.
acquired immunodeficiency syndrome, highly active antiretroviral therapy, human immunodeficiency virus, patient compliance, Sweden
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-95139DOI: 10.1111/j.1365-2710.2006.00782.xISI: 000242232900010PubMedID: 17176366OAI: oai:DiVA.org:uu-95139DiVA: diva2:169234