Microwave-accelerated spiro-cyclizations of o-halobenzyl cyclohexenyl ethers by palladium(0) catalysis
2007 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 72, no 15, 5851-5854 p.Article in journal (Refereed) Published
A number of new spiro[cyclohexane-1,1'-isobenzofuran]-based compounds was synthesized by palladium(0)-catalyzed 5-exo cyclization of a series of cyclohexenyl o-halobenzyl ethers. Controlled microwave heating was found to promote both product yield and reaction rate without compromising the selectivity. Heck cyclization of aryl iodide 6, 2-(2-iodobenzyloxy)cyclohex-2-enyl acetate, proceeded selectively without involvement of the allylic acetate functionality.
Place, publisher, year, edition, pages
2007. Vol. 72, no 15, 5851-5854 p.
Cyclization, Ethers, Microwaves, Palladium/*chemistry
IdentifiersURN: urn:nbn:se:uu:diva-95223DOI: 10.1021/jo0708487ISI: 000247992800053OAI: oai:DiVA.org:uu-95223DiVA: diva2:169352