Synthesis and circular dichroism spectroscopic investigations of oligomeric β-peptoids with α-chiral side chains
2006 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 8, no 20, 4533-4536 p.Article in journal (Refereed) Published
Biomimetic oligomers are of large interest both as targets for combinatorial and parallel synthetic efforts and as foldamers. For example, shorter peptoid derivatives of beta-peptides, i.e., oligo-N-substituted beta-Ala, have been described as potential lead structures. Herein, we describe a solid-phase synthetic route to beta-peptoids with alpha-chiral aromatic N-substituents up to 11 residues long. Furthermore, the folding propensities of these oligomers were investigated by circular dichroism (CD) spectroscopy.
Place, publisher, year, edition, pages
2006. Vol. 8, no 20, 4533-4536 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:uu:diva-95284DOI: 10.1021/ol061717fISI: 000240654700038PubMedID: 16986943OAI: oai:DiVA.org:uu-95284DiVA: diva2:169443