Disc formation in cholesterol-free liposomes during phase transition
2003 (English)In: Biochimica et Biophysica Acta - Biomembranes, ISSN 0005-2736, E-ISSN 1879-2642, Vol. 1614, no 2, 135-138 p.Article in journal (Refereed) Published
Cryogenic transmission electron microscopy (cryo-TEM) images of lysolipid-containing thermosensitive liposomes (LTSL) revealed that open liposomes and bilayer discs appeared when liposomes were cycled through the gel (Lbeta') to liquid-crystalline (Lalpha) phase transition. The amount of bilayer discs generated was dependent on the combined presence of PEG-lipid and lysolipid in the membrane. We hypothesize that micelle-forming membrane components stabilize the rim of bilayer openings and membrane discs that form when liposomes are cycled through TC.
Place, publisher, year, edition, pages
2003. Vol. 1614, no 2, 135-138 p.
thermosensitive liposome, lysolipid, PEG-lipid, disc formation
IdentifiersURN: urn:nbn:se:uu:diva-95513DOI: 10.1016/S0005-2736(03)00196-2PubMedID: 12896806OAI: oai:DiVA.org:uu-95513DiVA: diva2:169760