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The Prevalence and Quantification of Atherosclerosis in an Elderly Population Assessed by Whole-Body Magnetic Resonance Angiography
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
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2007 (English)In: Arteriosclerosis, Thrombosis and Vascular Biology, ISSN 1079-5642, E-ISSN 1524-4636, Vol. 27, no 3, 649-654 p.Article in journal (Refereed) Published
Abstract [en]

Objective-The principal aim of the present study was to explore the feasibility of using whole-body magnetic resonance angiography to assess atherosclerosis in different vascular territories in a cohort of elderly. Methods and Results-Three hundred six 70-year-old subjects (145 women, 161 men) recruited from a population-based cohort study (Prospective Investigation of the Vasculature in Uppsala Seniors, ie, the PIVUS study) underwent 1.5-T whole-body magnetic resonance angiography with gadodiamide. The arteries were divided into 26 segments. In total, 7956 vessel segments were evaluated with 7900 segments (99.3%) possible to evaluate. Of these, 7186 segments (91%) were normal. Luminal narrowing of ≥50% was observed in 9 (1.5%) of the renal arteries, 12 (1.8%) of the carotid arteries, in 31 segments (1.1%) of the pelvic/upper leg territories, and in 136 segments (6.2%) of territories in the lower leg. Approximately one-third of the sample had no vascular abnormalities, one-third had stenoses of <50%, and the remainder had stenoses ≥50% or occlusions. Six subjects (2%) had aortic aneurysms. In subjects without evident vascular disease, 26% had significant vascular abnormalities. Conclusions-Whole-body magnetic resonance angiography performed with a clinical scanner can be used for quantifying atherosclerosis in different vascular territories in a single examination in an elderly population.

Place, publisher, year, edition, pages
2007. Vol. 27, no 3, 649-654 p.
Keyword [en]
atherosclerosis, cardiovascular diseases, epidemiology, MRI, population
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-95652DOI: 10.1161/01.ATV.0000255310.47940.3bISI: 000244235400033PubMedID: 17170372OAI: oai:DiVA.org:uu-95652DiVA: diva2:169954
Available from: 2007-04-04 Created: 2007-04-04 Last updated: 2012-03-07Bibliographically approved
In thesis
1. Assessment of Atherosclerosis by Whole-Body Magnetic Resonance Angiography.
Open this publication in new window or tab >>Assessment of Atherosclerosis by Whole-Body Magnetic Resonance Angiography.
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Atherosclerosis is a serious threat to public health and a major cause of morbidity and mortality. In this doctoral research, the feasibility of using whole-body magnetic resonance angiography (WBMRA) was studied as a principal aim both in patients and in an epidemiological setting. Secondary aims were to create a score for assessment of the degree of atherosclerosis with the use of WBMRA and to investigate the correlation between this score and various cardiovascular (CV) risk factors.

WBMRA was found feasible both in atherosclerotic patients and in an elderly population from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS). All subjects except one completed the examination without any adverse events. A large proportion (93-99%) of the vessel segments could be evaluated and the results of a smaller comparison between WBMRA and conventional invasive x-ray angiography were reasonable regarding the assessed degree of maximum stenosis or occlusion. This indicates the safety and robustness of the WBMRA method.

Unsuspected significant vascular abnormalities were found in patients with atherosclerotic symptoms and significant vascular abnormalities were present in elderly subjects without any self-reported vascular disease. The prevalence rates of vascular abnormalities in the carotid, renal, and inflow and runoff arteries of the lower limbs were estimated in an elderly population. A total atherosclerotic score (TAS) reflecting the degree of luminal narrowing was created for the WBMRA method and was significantly related to Framingham risk score (FRS) and to the amount of abdominal visceral adipose tissue, interleukin-6, and leptin and was inversely significantly related to adiponectin.

Studies with outcome data of the PIVUS cohort are needed for further validation of the WBMRA method and to determine whether TAS can be used as an adjunct for CV risk assessment. Meanwhile, the correlation with FRS indicates that TAS could be of value for this purpose.

Place, publisher, year, edition, pages
Uppsala: Institutionen för onkologi, radiologi och klinisk immunologi, 2007. 53 p.
Keyword
Radiology, Atherosclerosis, Magnetic Resonance Angiography, Epidemiology, Radiologisk forskning
Identifiers
urn:nbn:se:uu:diva-7778 (URN)978-91-506-1926-3 (ISBN)
Public defence
2007-04-27, Grönwallsalen, Akademiska sjukhuset, Ing. 70, b.v., Uppsala, 09:15
Opponent
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Available from: 2007-04-04 Created: 2007-04-04Bibliographically approved

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Hansen, TomasWikström, JohanJohansson, LarsAhlström, Håkan

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