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Visceral adipose tissue, inflammation and adiponectin are related to atherosclerosis as assessed by whole-body magnetic resonance angiography in an elderly population.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
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URN: urn:nbn:se:uu:diva-95654OAI: oai:DiVA.org:uu-95654DiVA: diva2:169956
Available from: 2007-04-04 Created: 2007-04-04 Last updated: 2010-01-13Bibliographically approved
In thesis
1. Assessment of Atherosclerosis by Whole-Body Magnetic Resonance Angiography.
Open this publication in new window or tab >>Assessment of Atherosclerosis by Whole-Body Magnetic Resonance Angiography.
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Atherosclerosis is a serious threat to public health and a major cause of morbidity and mortality. In this doctoral research, the feasibility of using whole-body magnetic resonance angiography (WBMRA) was studied as a principal aim both in patients and in an epidemiological setting. Secondary aims were to create a score for assessment of the degree of atherosclerosis with the use of WBMRA and to investigate the correlation between this score and various cardiovascular (CV) risk factors.

WBMRA was found feasible both in atherosclerotic patients and in an elderly population from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS). All subjects except one completed the examination without any adverse events. A large proportion (93-99%) of the vessel segments could be evaluated and the results of a smaller comparison between WBMRA and conventional invasive x-ray angiography were reasonable regarding the assessed degree of maximum stenosis or occlusion. This indicates the safety and robustness of the WBMRA method.

Unsuspected significant vascular abnormalities were found in patients with atherosclerotic symptoms and significant vascular abnormalities were present in elderly subjects without any self-reported vascular disease. The prevalence rates of vascular abnormalities in the carotid, renal, and inflow and runoff arteries of the lower limbs were estimated in an elderly population. A total atherosclerotic score (TAS) reflecting the degree of luminal narrowing was created for the WBMRA method and was significantly related to Framingham risk score (FRS) and to the amount of abdominal visceral adipose tissue, interleukin-6, and leptin and was inversely significantly related to adiponectin.

Studies with outcome data of the PIVUS cohort are needed for further validation of the WBMRA method and to determine whether TAS can be used as an adjunct for CV risk assessment. Meanwhile, the correlation with FRS indicates that TAS could be of value for this purpose.

Place, publisher, year, edition, pages
Uppsala: Institutionen för onkologi, radiologi och klinisk immunologi, 2007. 53 p.
Radiology, Atherosclerosis, Magnetic Resonance Angiography, Epidemiology, Radiologisk forskning
urn:nbn:se:uu:diva-7778 (URN)978-91-506-1926-3 (ISBN)
Public defence
2007-04-27, Grönwallsalen, Akademiska sjukhuset, Ing. 70, b.v., Uppsala, 09:15
Available from: 2007-04-04 Created: 2007-04-04Bibliographically approved

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