Hepatitis C Virus NS3 Protease Inhibitors Comprising a Novel Aromatic P1 Moiety
2008 (English)In: Bioorganic & Medicinal Chemistry, ISSN 0968-0896, Vol. 16, no 6, 2955-2967 p.Article in journal (Refereed) Published
Inhibition of the hepatitis C virus (HCV) NS3 protease has emerged as an attractive approach to defeat the global hepatitis C epidemic. In this work, we present the synthesis and biochemical evaluation of HCV NS3 protease inhibitors comprising a non-natural aromatic P-1 moiety. A series of inhibitors with aminobenzoyl sulfonamides displaying submicromolar potencies in the full-length NS3 protease assay was prepared through a microwave-irradiated, palladium-catalyzed, amidocarbonylation protocol.
Place, publisher, year, edition, pages
2008. Vol. 16, no 6, 2955-2967 p.
HCV, NS3, protease inhibitor, carbonylation, acyl sulfonamide, palladium
IdentifiersURN: urn:nbn:se:uu:diva-95748DOI: 10.1016/j.bmc.2007.12.041ISI: 000255127700023PubMedID: 18194867OAI: oai:DiVA.org:uu-95748DiVA: diva2:170076