Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor
2008 (English)In: Journal of Molecular Graphics and Modelling, ISSN 1093-3263, Vol. 26, no 6, 991-1003 p.Article in journal (Refereed) Published
The 3D model of the AT(2) receptor has been built employing homology to the transmembrane domain of rhodopsin and a novel build-up procedure for restoring the extracellular loops. By docking a model peptide of angiotensin II in the AT(2) receptor model two plausible binding modes were identified. These binding modes were in agreement with most of the suggested ligand-receptor contact points reported in the literature. Eight active and one inactive pseuclopeptide angiotensin II analogue were also docked in the receptor and four of the active pseudopeptides were found to mimic the binding mode of angiotensin II. An alternative binding mode for the other four active pseudopeptides was found.
Place, publisher, year, edition, pages
2008. Vol. 26, no 6, 991-1003 p.
AT(2) receptor, angiotensin II, homology modeling, docking, bioactive conformation
IdentifiersURN: urn:nbn:se:uu:diva-95770DOI: 10.1016/j.jmgm.2007.08.005ISI: 000253068700012PubMedID: 17936050OAI: oai:DiVA.org:uu-95770DiVA: diva2:170106