uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Plasma for transfusion: Effects of donor gender and different preparation and storage procedures
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Clinical Immunology.
Show others and affiliations
Manuscript (Other academic)
URN: urn:nbn:se:uu:diva-95818OAI: oai:DiVA.org:uu-95818DiVA: diva2:170164
Available from: 2007-04-19 Created: 2007-04-19 Last updated: 2010-01-13Bibliographically approved
In thesis
1. Plasma as a Therapeutic Principle in Clinical Practice: With Special Reference to Sweden
Open this publication in new window or tab >>Plasma as a Therapeutic Principle in Clinical Practice: With Special Reference to Sweden
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The newly established Swedish Apheresis Registry makes it possible to do national inter-center comparisons. This study was undertaken to describe and analyze the use of therapeutic apheresis and the adverse effects in such therapy. The special case of plasma exchange as rescue therapy in multi-organ failure, including renal failure, was also studied. In Sweden, plasma for transfusion is prepared and stored to ensure rapid availability. Due to new EU legislation, validation of such plasma was performed.

The analysis indicated that the use of therapeutic apheresis was in line with recommendations of other international societies. The frequency and types of adverse effects were comparable to those reported in other studies from analogous time periods. Compared with other countries, it appears that more therapeutic resources are available in Sweden and that there is a lower frequency of adverse effects in specific procedures. No fatalities were reported. The unique comparison of differences between centers regarding plasma exchange identified areas for further improvement.

The study on plasma exchange as rescue therapy in severe sepsis or septic shock is the second largest reported. The result was promising, with a survival rate of 82%. The rapid availability of plasma for transfusion appears to be of clinical importance in patients with early coagulopathy and severe trauma but the present selection and storage procedures for plasma lead to a time-dependent increase of the number of units with cold-induced activation of the contact system and C1 inhibitor consumption before day 14. Improvements of plasma quality can be attained by using plasma from male donors only and by reducing the storage time from 14 to 7 days.

Further studies are needed to define the role of plasma exchange in severe sepsis/septic shock, to evaluate the outcome of each patient’s treatment and to establish the indications for the transfusion of plasma.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2007. 69 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 255
Immunology, adverse effects, contact activation, plasma exchange, plasma storage, severe sepsis, therapeutic apheresis, transfusion, Immunologi
urn:nbn:se:uu:diva-7838 (URN)978-91-554-6877-4 (ISBN)
Public defence
2007-05-10, Rudbecksalen, Rudbecklaboratoriet, Dag Hammarskjölds väg 20, Uppsala, 09:15
Available from: 2007-04-19 Created: 2007-04-19Bibliographically approved

Open Access in DiVA

No full text

By organisation
Clinical Immunology

Search outside of DiVA

GoogleGoogle Scholar

Total: 133 hits
ReferencesLink to record
Permanent link

Direct link