By taking a complex factorization of the Schur complement matrix into consideration, we present practical expressions for the inverses of a class of complex valued block two-by-two matrices. Then, based on the obtained practical inverse expressions, some efficient exact inverse solution methods are presented for solving the related linear systems within both iterative refinement and Krylov subspace accelerations. Numerical experiments indicate that in most cases the proposed exact inverse methods perform better than the MINRES and GMRES methods accelerated by some existing efficient preconditioners.