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Measurement accuracy of aluminium content in bone
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
2000 (English)In: Uppsala Journal of Medical Sciences, ISSN 0300-9734, Vol. 105, no 1, 67-71 p.Article in journal (Refereed) Published
Abstract [en]

The aluminium content in bone has been related in several ways: to the weight of wet bone, to the weight of dry bone, to the weight of bone-ash and to the calcium content of bone. We determined the accuracy and precision of measurement (using an inductively coupled mass-spectrometer) in 30 bone samples taken from one patient. The coefficient of variation of the aluminium/weight-quotient was 12.4 per cent for wet bone, 4.7 for dry bone and 5.0 for bone ash; and the coefficient of variation of the aluminium/calcium-weight-quotient was 7.5 per cent. Thus, the aluminium content in bone seems to be best related to the weight of dry bone.

Place, publisher, year, edition, pages
2000. Vol. 105, no 1, 67-71 p.
Keyword [en]
bone, aluminium content
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-96127PubMedID: 10893054OAI: oai:DiVA.org:uu-96127DiVA: diva2:170600
Available from: 2007-09-07 Created: 2007-09-07 Last updated: 2009-02-16Bibliographically approved
In thesis
1. Bone and Aluminium
Open this publication in new window or tab >>Bone and Aluminium
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Osteoporosis is a major health care problem, by reason of its devastating consequences, in particular hip fractures. Worldwide it has been estimated that the incidence of hip fracture will increase to more than 6 million per year by 2050 compared to 1.7 million per year in 1990. Osteoporosis can be caused by various factors namely, genetic, lifestyle and environmental factors, and since the rising incidence of its consequences is not fully explained by the growing age of the population, there is an urgent need to identify individual causal factors of this condition.

The present research has focused on aluminium, one potential environmental factor of importance for bone disease, and its possible relation to osteoporosis, since it is known to cause osteoporosis-like bone disease and has been associated with induction of progressive central nervous system diseases.

Aluminium is the third most common element in the earth’s crust and the most abundant metal (8%). It is widely utilized industrially and it is also naturally present in many foods. Although aluminium is ubiquitous in the human environment, evolution has not given it an essential biological function.

The aluminium content of bone was measured by inductively coupled mass spectrometry in a large group of patients suffering from hip fractures, high energy fractures and osteoarthrosis. An exponential increase in aluminium content of bone with age was found (p=0.0004). However, no significant association of aluminium in bone with occurrence of hip fracture or dementia could be found, and no indirect evidence was obtained, e.g. through bone mineral density or biomechanical properties, that aluminium is involved in the pathogenesis of osteoporosis. Although we accumulate aluminium in bone throughout our lives, and there are experimental suggestions that aluminium induces premature cell death, the body content of this metal does not seem to influence the overall mortality risk.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2007. 86 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 271
Surgery, Aluminium, Osteoporosis, Hip fracture, Osteoporotic fracture, Alzheimer´s dementia, Bone mineral density, Bone mineral content, Mortality risk, Biomechanics, Inductively coupled mass spectrometry, Kirurgi
urn:nbn:se:uu:diva-8181 (URN)978-91-554-6951-1 (ISBN)
Public defence
2007-09-28, Rosénsalen, Ingång 95/96, Akademiska sjukhuset (Barnsjukhuset), 751 85 Uppsala, Uppsala, 09:15
Available from: 2007-09-07 Created: 2007-09-07Bibliographically approved

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