No association between the aluminium content of trabecular bone and bone density, mass or size of the proximal femur in elderly men and women
2006 (English)In: BMC Musculoskeletal Disorders, ISSN 1471-2474, Vol. 7, 69- p.Article in journal (Refereed) Published
BACKGROUND: Aluminium is considered a bone toxic metal since poisoning can lead to aluminium-induced bone disease in patients with chronic renal failure. Healthy subjects with normal renal function retain 4% of the aluminium consumed. They might thus also accumulate aluminium and eventually be at risk of long-term low-grade aluminium intoxication that can affect bone health. METHODS: We therefore examined 62 patients with femoral neck fractures or osteoarthritis of the hip (age range 38-93), with the aim of examining whether aluminium in bone is associated with bone-mineral density (BMD), content (BMC) or width of the femoral neck measured by dual-energy X-ray absorptiometry (DXA). During operations bone biopsies were taken from the trabecular bone of the proximal femur. The samples were measured for their content of aluminium using a mass spectrometer. RESULTS: No significant association between the aluminium content in bone and femoral neck BMD, BMC or width could be found after multivariate adjustment. CONCLUSION: Our results indicate that the accumulated aluminium content in bone during life does not substantially influence the extent of osteoporosis.
Place, publisher, year, edition, pages
2006. Vol. 7, 69- p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-96129DOI: 10.1186/1471-2474-7-69ISI: 000240454400001PubMedID: 16928265OAI: oai:DiVA.org:uu-96129DiVA: diva2:170602