Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs
2007 (English)In: Bioorganic & Medicinal Chemistry, ISSN 0968-0896, E-ISSN 1464-3391, Vol. 15, no 12, 4016-4037 p.Article in journal (Refereed) Published
Agelasine and agelasimine derivatives with substantially less complicated terpenoid side chains compared to the naturally occurring compounds have been synthesized and their ability to inhibit growth of microorganisms and cancer cells has been studied. Compounds with excellent activity against cancer cell lines (MIC ca. 1 μM for the most potent compounds), including a drug resistant renal cell line, have been identified. Most compounds studied also exhibited broad spectrum antimicrobial activity including activity against Mycobacterium tuberculosis.
Place, publisher, year, edition, pages
2007. Vol. 15, no 12, 4016-4037 p.
Antimicrobial agent, Anti-cancer agent, Adenine derivative, Natural product
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-96232DOI: 10.1016/j.bmc.2007.03.086ISI: 000246870400007PubMedID: 17442577OAI: oai:DiVA.org:uu-96232DiVA: diva2:170735