Screening for biomarkers in plasma from patients with gangrenous phlegmonous appendicitis using CE and CEC in combination with MS
2007 (English)In: Electrophoresis, ISSN 0173-0835, E-ISSN 1522-2683, Vol. 28, no 9, 1435-1443 p.Article in journal (Refereed) Published
Today a high degree of "false" appendicitis diagnoses are occurring. In this study, a screening experiment of biomarkers of two different kinds of appendicitis, gangrenous and phlegmonous, were conducted with CE and CEC coupled to MS. Plasma samples were obtained from patients pre- and post-surgery. A large amount of data was generated to be able to compare them, and chemometrics tools were utilized to visualize the differences. Indicative patterns were found for both pre- and post-surgery of the two types of inflammation as well as between them. The divergences were traced back to the MS peaks obtained in the CE- and CEC-MS setups as possible biomarkers for the two forms of appendicitis.
Place, publisher, year, edition, pages
2007. Vol. 28, no 9, 1435-1443 p.
Appendicitis, Biomarker, Fourier transform ion cyclotron resonance-MS, Open tubular CEC, TOF-MS
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-96249DOI: 10.1002/elps.200600606ISI: 000246557400018PubMedID: 17372941OAI: oai:DiVA.org:uu-96249DiVA: diva2:170758