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Identification of proteomics signatures of exposure to marine pollutants in mussels (Mytilus edulis)
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Cell and Molecular Biology.
2006 In: Molecular & Cellular Proteomics, ISSN 1535-9476, Vol. 5, no 7, 1274-1285 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2006. Vol. 5, no 7, 1274-1285 p.
URN: urn:nbn:se:uu:diva-96432OAI: oai:DiVA.org:uu-96432DiVA: diva2:171003
Available from: 2007-11-15 Created: 2007-11-15Bibliographically approved
In thesis
1. Proteomic Analysis of Peroxisomal Proteins
Open this publication in new window or tab >>Proteomic Analysis of Peroxisomal Proteins
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Peroxisome is a ubiquitous eukaryotic organelle with a single-layer membrane. It maintains various functions that differ depending on the species and cell types, as well as the environmental or developmental conditions.

In the first part of this thesis, the peroxisomal protein content was systematically analyzed in different organs in mouse from different ages using proteomic approaches. Thirty-one peroxisomal proteins were identified and ten putative peroxisomal proteins were suggested. The results indicate that peroxisomal proteins show a tissue-specific functional response to the aging process that is probably dependent on their differential regeneration capacity. Besides, alteration in the fatty acid metabolism could alter membrane protein functions; decrease in catalase expression in kidney may contribute to oxidative stress and isoprenoid biosynthesis could contribute to decline in bile salt synthesis. The ability to detect changes in the peroxisomal proteome associated with organ impairment during the course of aging would provide a conceptual framework to understand the role of peroxisome in aging.

In the second part, peroxisome proteomics was used as a novel approach in marine pollution assessment. The peroxisomal protein expression profiles were obtained and identified from mussel Mytilus sp. exposed to different pollutants, in both laboratory and field experiments. The identified proteins were involved in α- and β–oxidation pathways, xenobiotics and amino acid metabolism, cell signalling, oxyradical metabolism, peroxisomal assembly, respiration and cytoskeleton pathway, etc. Generally, these findings suggest that protein expression signatures could become a valuable tool to monitor the presence of pollutants in marine environment.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2007. 54 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 365
Cell and molecular biology, peroxisome, proteomics, biomarker, aging, pollution assessment, Cell- och molekylärbiologi
urn:nbn:se:uu:diva-8307 (URN)978-91-554-7020-3 (ISBN)
Public defence
2007-12-08, C10:305, Biomedical Center, Husarg. 3, Uppsala, 10:00
Available from: 2007-11-15 Created: 2007-11-15Bibliographically approved

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