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variants interact with the MHC class I locus in the Swedish psoriasis population
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
In: The Journal of Investigative DermatologyArticle in journal (Refereed) Submitted
URN: urn:nbn:se:uu:diva-96502OAI: oai:DiVA.org:uu-96502DiVA: diva2:171098
Available from: 2007-11-21 Created: 2007-11-21Bibliographically approved
In thesis
1. The Genetics of Systemic Lupus Erythematosus: The Specificity of IRF5 to SLE.
Open this publication in new window or tab >>The Genetics of Systemic Lupus Erythematosus: The Specificity of IRF5 to SLE.
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The breakdown of self-tolerance is the main driving force behind susceptibility to SLE. When this occurs, T and B cells are activated in an uncontrolled manner and produce autoantibodies against self fragmented DNA, RNA and sometimes other parts of the cell such as cardiolipin, phosphatidylserine, etc.

The mechanism behind the breakdown of self-tolerance may be genetic factors that are triggered by environmental factors. SLE is not caused by a single gene, but by many genes, and is thus a polygenic disease. So far only a few genes have been found to be associated with SLE including PDCD1, FcγRs, and PTPN22. The main aim of my thesis is to find susceptibility genes responsible for SLE.

Recently, a gene called IRF5 was found to be associated with SLE. In paper one, we performed a thorough study and confirmed its association to SLE. In addition, we found a few other SNPs in the gene that were associated to the disease. Among them, SNP rs2004640 is very strongly associated and was found to affect the splicing of the gene. Another SNP, rs2280714, correlated with overexpression of the gene, although SNP rs10954213 was much more highly correlated with expression adding to this, in paper two we found a few other SNPs that were associated to SLE and played crucial roles in gene function. An indel in exon 6, though not associated by itself, regulated which isoforms were expressed. Individuals with 2 repeats expressed isoforms V1 and V4, while individuals with 4 repeats expressed isoforms V5 and V6. SNP rs2070197 was also very strongly associated, but did not have a functional role. In paper three, the same polymorphisms were studied in a Mexican population, which showed an even stronger association when compared to a European population.

It is known that autoimmune diseases share susceptibility genes, therefore we wanted to see if the IRF5 gene is associated with any other autoimmune diseases. In papers four and five, we tested its association to RA (using three sets of patients and controls from Sweden, Argentina and Spain) and psoriasis (using a set of patients and controls from Sweden). Association was not found in either of the diseases. Therefore, we believe that this association may be SLE-specific.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2007. 79 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 296
Molecular genetics, Systemic lupus erythematosus, Interferon regulatory factor 5, Transmission-Disequilibrium Test, Family-based association test, Linkage Disequilibrium, Hardy-Weinberg equilibrium, Genetik
urn:nbn:se:uu:diva-8332 (URN)978-91-554-7038-8 (ISBN)
Public defence
2007-12-12, Rudbecksalen, Rudbeck Laboratory, 09:15
Available from: 2007-11-21 Created: 2007-11-21Bibliographically approved

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