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Study of the relation between the incidence of uterine leiomyomas and the concentrations of PCB and DDT in Baltic gray seals
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
2008 (English)In: Reproductive Toxicology, ISSN 0890-6238, Vol. 25, no 2, 247-255 p.Article in journal (Refereed) Published
Abstract [en]

Exposure to environmental contaminants is believed to be associated with the previously described decrease in the reproduction rate of Baltic gray seals. In the present study the prevalence of uterine leiomyomas was investigated in 257 Baltic gray seal females examined during 1973-2007, in relation to the levels of polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDT) in Baltic biota, using an estimated exposure index. Additionally, the proliferative activity in leiomyomas, occurrence of corpora lutea, and blubber concentrations of PCB and DDT were investigated in a subset of females. Leiomyomas were only found in females 22-41 years old, at a prevalence of 65%. No differences in blubber concentrations of PCB or DDT were detected between the subset of leiomyoma-bearing females and reference females, but the estimated exposure index indicated that the PCB level in Baltic biota might be related to the leiomyoma prevalence in Baltic gray seal females.

Place, publisher, year, edition, pages
2008. Vol. 25, no 2, 247-255 p.
Keyword [en]
Baltic gray seal, Uterine leiomyoma, Myoma, Prevalence, PCB, DDT, Exposure, Proliferation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-96509DOI: 10.1016/j.reprotox.2007.11.008ISI: 000254723400014PubMedID: 18187284OAI: oai:DiVA.org:uu-96509DiVA: diva2:171107
Available from: 2007-11-22 Created: 2007-11-22 Last updated: 2009-11-11Bibliographically approved
In thesis
1. Effects of some Endocrine Disruptors on Human and Grey Seal Uterine Cells
Open this publication in new window or tab >>Effects of some Endocrine Disruptors on Human and Grey Seal Uterine Cells
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The effects of environmental contaminants in humans and animals are of great concern. Some contaminants are endocrine disruptors that may interfere with the endogenous hormonal signalling and disturb, for example, reproductive organs and functions.

Primary uterine myometrial cells originating from women and Baltic grey seals were exposed to some polychlorinated biphenyls (PCBs) and their metabolites. Even though human and Baltic grey seal myometrial cells responded differently to the tested PCBs, the results indicate that PCBs can influence myometrial cell proliferation in vitro.

The prevalence of uterine leiomyomas was investigated among 257 Baltic grey seals. Leiomyomas were only present in females older than 22 years, at a prevalence of 65%. Proliferation in leiomyoma cells was detected in individuals lacking ovarian proliferation support, suggesting the presence of an exogenous stimulant. By taking into account temporal alterations in the contaminant burden of the seals, PCB exposure was found to be associated with leiomyoma prevalence. In conclusion, PCB exposure may be related to uterine leiomyoma development and proliferation in Baltic grey seals in vivo.

Human endometrial endothelial cells (HEECs) were exposed to some endocrine disruptors, and the effects of the endocrine disruptors on cell proliferation and viability were studied. All evaluated endocrine disruptors decreased HEEC proliferation and most also decreased HEEC viability. Further studies revealed that the reduction in HEEC proliferation after exposure to o,p’-DDT was associated with differential expression of mRNA involved in proliferation, defence response, and lipid and cholesterol metabolism compared to untreated HEEC.

In conclusion, these studies suggest that endocrine disruptors affect cultured cells from the female reproductive tract of humans and grey seals, and may have deleterious effects on proliferation, viability, and genes involved in defence response, and lipid or cholesterol metabolism.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2007. 105 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 298
Keyword
Obstetrics and gynaecology, Reproductive toxicology, Baltic grey seal, leiomyoma, myometrial cells, endometrial endothelial cells, hormones, endocrine disruptors, Obstetrik och kvinnosjukdomar
Identifiers
urn:nbn:se:uu:diva-8334 (URN)978-91-554-7041-8 (ISBN)
Public defence
2007-12-14, Rosénsalen, Department of Women's and Children's Health, Uppsala University Hospital entrance 95/96, 09:15
Opponent
Supervisors
Available from: 2007-11-22 Created: 2007-11-22Bibliographically approved

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