T cell control of primary and latent cytomegalovirus infections in healthy subjects
2005 (English)In: Journal of Clinical Immunology, ISSN 0271-9142, E-ISSN 1573-2592, Vol. 25, no 5, 473-481 p.Article in journal (Refereed) Published
The T cell repertoire required to control acute and latent CMV infection in otherwise healthy individuals was examined using both functional analysis and a wide range of MHC I tetramers. Both frequency and function of CMV specific T cells varied considerably between subjects, however, within subjects values remained stable over time. In total 16 ± 3.5 CMV specific T cells/μl blood was detected, with obvious immunodominance between different CMV epitopes. Most subjects with latent infection showed low CMV specific T cell activity, whereas a subgroup (1/3) of individuals was high in either frequency or function of their CMV specific T cells. Patients with acute infection displayed high initial, but rapidly decreasing, numbers of CMV specific cells. In conclusion, a majority of healthy individuals readily seem to control latent CMV infection, whereas a subpopulation (1/3) of individuals uses a large proportion of their CD8+ T cell repertoire to control the infection.
Place, publisher, year, edition, pages
2005. Vol. 25, no 5, 473-481 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-96910DOI: 10.1007/s10875-005-5372-8PubMedID: 16160916OAI: oai:DiVA.org:uu-96910DiVA: diva2:171643