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Apolipoprotein E epsilon 4 genotype is independently associated with increased intima-media thickness in a recessive pattern
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.ORCID iD: 0000-0003-2247-8454
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2007 (English)In: Lipids, ISSN 0024-4201, E-ISSN 1558-9307, Vol. 42, no 5, 451-456 p.Article in journal (Refereed) Published
Abstract [en]

Polymorphisms in the apolipoprotein E (Apo E) gene have been associated with lipid levels, carotid intima media thickness (CCA-IMT), inflammation and cardiovascular disease (CVD). Earlier findings suggested an association of the Apo E alleles with increased CCA-IMT following a recessive pattern. Whether associations might be independent of C-reactive protein (CRP), lipid levels and other CVD risk factors is not known. We investigated the relationships between Apo E (epsilon2, epsilon3 and epsilon4 alleles) and CCA-IMT, measured by B-mode ultrasound, in dominant and recessive models in a community-based sample of 437 men 75 years of age. In men homozygous for the epsilon4 allele CCA-IMT was significantly increased by 0.13 mm to 0.86 +/- 0.16 mm compared to 0.73 +/- 0.19 mm in non- epsilon4-carriers (P = 0.0012) and 0.73 +/- 0.21 mm in epsilon4 heterozygous (P = 0.0044) in unadjusted recessive models. The association between Apo E epsilon4 genotype and CCA-IMT was independent of Apo E epsilon2 and Apo E epsilon3 alleles, CRP, lipid variables (TG, LDL, HDL) and other CVD risk factors (smoking, hypertension, body mass index, diabetes) (P = 0.018). No relations between Apo E genotype and CCA-IMT were observed in dominant models. No significant associations between the Apo E epsilon2 and epsilon3 alleles and CCA-IMT were found. In this study, men homozygous with the ApoE epsilon4 allele had thicker CCA-IMT, independently of Apo E epsilon2 and epsilon3 alleles, CRP, lipid variables (TG, LDL, HDL) and other CVD risk factors (smoking, hypertension, body mass index, diabetes), suggesting CCA-IMT to be modified by the ApoE epsilon4 genotype in a recessive pattern.

Place, publisher, year, edition, pages
2007. Vol. 42, no 5, 451-456 p.
Keyword [en]
Apolipoprotein E, Carotid, Genotype, Intima-media, Ultrasound
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-97039DOI: 10.1007/s11745-007-3045-5ISI: 000246204500006PubMedID: 17426996OAI: oai:DiVA.org:uu-97039DiVA: diva2:171816
Available from: 2008-04-25 Created: 2008-04-25 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Carotid Vessel Wall Thickness and Echogenicity: In the ULSAM study
Open this publication in new window or tab >>Carotid Vessel Wall Thickness and Echogenicity: In the ULSAM study
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In this thesis the common carotid artery intima media thickness in nearly 500 elderly men is independently associated with insulin sensitivity, measured by the gold standard hyperinsulinemic euglycemic clamp test (paper 1), to both COX- and cytokine mediated inflammation independently of other markers of inflammation, oxidative stress and antioxidant status (paper 2) and also to the alleles of the apolipoprotein gene independently of lipid levels and cardiovascular risk factors (paper 3). The echogenicity of the carotid intima-media complex measured as grey scale median predicts mortality independently of common carotid artery intima-media thickness, prior cardiovascular disease and cardiovascular risk factors (paper 4).

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2008. 106 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 332
Keyword
Medicine, Epidemiology, Medicin
Identifiers
urn:nbn:se:uu:diva-8642 (URN)978-91-554-7161-3 (ISBN)
Public defence
2008-05-09, Robergsalen, ingång 40 plan 4, Akademiska sjukhuset, Uppsala, 13:15 (English)
Opponent
Supervisors
Available from: 2008-04-25 Created: 2008-04-25 Last updated: 2009-10-06Bibliographically approved

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Wohlin, MartinSundström, JohanLannfelt, LarsAxelsson, TomasSyvänen, Ann-ChristineAndrén, BertilBasu, SamarLind, Lars

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