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Prenatal X-ray and childhood brain tumours: A population-based case-control study on tumour subtypes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Obstetrisk forskning/Axelsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Obstetrisk forskning/Axelsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Obstetrisk forskning/Axelsson)
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2007 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 97, no 11, 1583-1587 p.Article in journal (Refereed) Published
Abstract [en]

We investigated childhood brain tumours by histological subtype in relation to prenatal X-ray among all children, less than 15 years of age, born in Sweden between 1975 and 1984. For each case, one control was randomly selected from the Medical Birth Register, and exposure data on prenatal X-ray were extracted blindly from antenatal medical records. Additional information on maternal reproductive history was obtained from the Medical Birth Register. We found no overall increased risk for childhood brain tumour after prenatal abdominal X-ray exposure (adjusted odds ratio (OR): 1.02, 95% confidence interval (CI): 0.64–1.62); primitive neuroectodermal tumours had the highest risk estimate (OR: 1.88, 95% CI: 0.92–3.83).

Place, publisher, year, edition, pages
2007. Vol. 97, no 11, 1583-1587 p.
Keyword [en]
brain tumour, childhood, X-ray, epidemiology
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-97112DOI: 10.1038/sj.bjc.6604046ISI: 000251172700019PubMedID: 17971773OAI: oai:DiVA.org:uu-97112DiVA: diva2:171909
Available from: 2008-04-25 Created: 2008-04-25 Last updated: 2011-01-14Bibliographically approved
In thesis
1. Prenatal Ultrasound and X-ray - Potentially Adverse Effects on the CNS
Open this publication in new window or tab >>Prenatal Ultrasound and X-ray - Potentially Adverse Effects on the CNS
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aim with this thesis was to assess the impact of prenatal ultrasound exposure on psychotic illness, childhood brain tumors (CBT) and school achievement, and to evaluate prenatal X-ray exposure and the risk of CBT.

In a cohort study, children born in Malmö 1973-1978, where prenatal ultrasound was used routinely, were considered exposed (n=13, 212) and children born at hospitals with no use of ultrasound, were considered unexposed (n=357,733). Exposed men had a tendency toward a higher risk of schizophrenia. For other psychoses there were no differences between groups. Other factors related to place of birth might have influenced the results.

In a case control study, children born 1975-1984 with a diagnosis of CBT (n=512), and randomly selected control children (n=524) were included. Exposure data on X-ray and ultrasound from antenatal records was completed with information from the Medical Birth Register. We found no overall increased risk for CBT after prenatal X-ray exposure. When stratifying by histological subgroups, primitive neuroectodermal tumors had the highest risk estimates. For ultrasound exposure, no increased risk for CBT was seen and numbers of examinations or gestational age at exposure had no substantial impact on the results.

In a follow-up of a randomized trial on prenatal ultrasound scanning 1985-87, we assessed the children’s school grades when graduating from primary school (15-16 years of age). We performed analyses according to randomization, ultrasound exposure in the second trimester and exposure at any time during pregnancy. There were no differences in school performance for boys or girls according to randomization or exposure in the second trimester. Boys exposed to ultrasound any time during fetal life had a reduced mean score in physical education and small, non-significant increased risk of poor school performance in general.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2008. 44 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 339
Keyword
Obstetrics and gynaecology, ultrasound, X-ray, fetus, risk, childhood cancer, schizophrenia, Obstetrik och kvinnosjukdomar
Identifiers
urn:nbn:se:uu:diva-8666 (URN)978-91-554-7175-0 (ISBN)
Public defence
2008-05-16, Rosénsalen, Ingång 95/96 nb, Akademiska Sjukhuset, Uppsala, 13:15
Opponent
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Available from: 2008-04-25 Created: 2008-04-25Bibliographically approved

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Stålberg, KarinHaglund, BengtPfeifer, Susan

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