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Prenatal ultrasound exposure and children’s school performance at age 15-16; follow-up of a randomised controlled trial
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Obstetrisk forskning/Axelsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Obstetrisk forskning/Axelsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Obstetrisk forskning/Axelsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
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2009 (English)In: Ultrasound in Obstetrics and Gynecology, ISSN 0960-7692, E-ISSN 1469-0705, Vol. 34, no 3, 297-303 p.Article in journal (Refereed) Published
Abstract [en]

Objective To evaluate the association between prenatal ultrasound exposure and school performance at 15-16 years of age. Methods The study population consisted of children born to women who participated in a randomized controlled trial on the second-trimester ultrasound examination in Sweden from 1985 to 1987. Information about the children's grades when graduating from primary school and information on socioeconomic factors was obtained from Swedish nationwide registers. Comparisons were made using linear and logistic regression analyses according to randomization to ultrasound, ultrasound exposure in the second trimester and ultrasound exposure at an), time during pregnancy. Boys and girls were analyzed separately. Results Of the 4756 singleton children from the randomized trial, we identified 4458 (94%) in the National School Register. There were no statistically significant differences in school performance for boys or girls according to randomization or exposure to ultrasound in the second trimester. Compared to those who were unexposed, boys exposed to ultrasound at least once at any time during fetal life bad a tendency towards lower mean school grades in general (-4.39 points; 95% CI, -9.59 to 0.81. (max possible, 320) points) and in physical education (-0.45 points; 95% CI, -0.91 to 0.01 (max possible, 20) points), but the differences did not reach significance. Conclusion In general, routine ultrasound examination in the second trimester bad no effect on overall school performance in teenagers.

Place, publisher, year, edition, pages
2009. Vol. 34, no 3, 297-303 p.
Keyword [en]
epidemiology, prenatal ultrasound, randomized controlled trial, school performance
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-97114DOI: 10.1002/uog.7332ISI: 000269867500010PubMedID: 19705400OAI: oai:DiVA.org:uu-97114DiVA: diva2:171911
Available from: 2008-04-25 Created: 2008-04-25 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Prenatal Ultrasound and X-ray - Potentially Adverse Effects on the CNS
Open this publication in new window or tab >>Prenatal Ultrasound and X-ray - Potentially Adverse Effects on the CNS
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aim with this thesis was to assess the impact of prenatal ultrasound exposure on psychotic illness, childhood brain tumors (CBT) and school achievement, and to evaluate prenatal X-ray exposure and the risk of CBT.

In a cohort study, children born in Malmö 1973-1978, where prenatal ultrasound was used routinely, were considered exposed (n=13, 212) and children born at hospitals with no use of ultrasound, were considered unexposed (n=357,733). Exposed men had a tendency toward a higher risk of schizophrenia. For other psychoses there were no differences between groups. Other factors related to place of birth might have influenced the results.

In a case control study, children born 1975-1984 with a diagnosis of CBT (n=512), and randomly selected control children (n=524) were included. Exposure data on X-ray and ultrasound from antenatal records was completed with information from the Medical Birth Register. We found no overall increased risk for CBT after prenatal X-ray exposure. When stratifying by histological subgroups, primitive neuroectodermal tumors had the highest risk estimates. For ultrasound exposure, no increased risk for CBT was seen and numbers of examinations or gestational age at exposure had no substantial impact on the results.

In a follow-up of a randomized trial on prenatal ultrasound scanning 1985-87, we assessed the children’s school grades when graduating from primary school (15-16 years of age). We performed analyses according to randomization, ultrasound exposure in the second trimester and exposure at any time during pregnancy. There were no differences in school performance for boys or girls according to randomization or exposure in the second trimester. Boys exposed to ultrasound any time during fetal life had a reduced mean score in physical education and small, non-significant increased risk of poor school performance in general.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2008. 44 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 339
Keyword
Obstetrics and gynaecology, ultrasound, X-ray, fetus, risk, childhood cancer, schizophrenia, Obstetrik och kvinnosjukdomar
Identifiers
urn:nbn:se:uu:diva-8666 (URN)978-91-554-7175-0 (ISBN)
Public defence
2008-05-16, Rosénsalen, Ingång 95/96 nb, Akademiska Sjukhuset, Uppsala, 13:15
Opponent
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Available from: 2008-04-25 Created: 2008-04-25Bibliographically approved

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