Ki67 and cyclin A as prognostic factors in early breast cancer: What are the optimal cut-off values?
2007 (English)In: Histopathology, ISSN 0309-0167, E-ISSN 1365-2559, Vol. 51, no 4, 491-498 p.Article in journal (Refereed) Published
AIMS: To find the optimal cut-off values for cyclin A and Ki67 in early breast cancer tumours and to evaluate their prognostic values. METHODS AND RESULTS: Tissue microarray (TMA) slides were constructed from 570 T1-4 N0-1 M0 breast cancer tumours. The TMA slides were stained for cyclin A and Ki67 using immunohistochemistry with commercial antibodies. To investigate the optimal cut-off values for cyclin A, Ki67 average and maximum values the material was split into two parts at cut-offs defined by dividing it into deciles. For each cut-off value the relative risk (RR) for metastasis-free survival (MFS) and overall survival (OS) was calculated comparing patients with high versus low cyclin A or Ki67 expression. When using a cut-off value around the seventh decile, cyclin A and Ki67 score correlated with the highest RR ratio for MFS in the chemotherapy-naïve subgroup. Among patients having received adjuvant chemotherapy, no statistically significant differences in MFS or OS were found. CONCLUSIONS: The optimal cut-off value for cyclin A average is 8% and for cyclin A maximum value 11%; for Ki67 the corresponding values are 15% and 22%. Additional studies are needed to verify these results.
Place, publisher, year, edition, pages
2007. Vol. 51, no 4, 491-498 p.
breast cancer, cut-off value, cyclin A, Ki67, tissue microarray
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-97139DOI: 10.1111/j.1365-2559.2007.02798.xISI: 000249661900008PubMedID: 17711446OAI: oai:DiVA.org:uu-97139DiVA: diva2:171944