Modeling of 24-Hour Glucose and Insulin Profiles of Patients With Type 2 Diabetes
2011 (English)In: Journal of clinical pharmacology, ISSN 0091-2700, E-ISSN 1552-4604, Vol. 51, no 2, 153-164 p.Article in journal (Refereed) Published
A model able to simultaneously characterize and simulate 24-hour glucose and insulin profiles following multiple meal tests was developed, extending an integrated glucose-insulin model for oral glucose tolerance tests that was previously published. The analysis was based on glucose and insulin measurements from 59 placebo-treated patients with type 2 diabetes. Circadian variations in glucose homeostasis were assessed on relevant parameters based on literature review. They were best described by a nighttime dip in insulin secretion between approximately 9 p.m. and 5 a.m. using a modulator function. The integrated glucose-insulin model has thus been shown to be applicable to real-life situations determined by multiple meals over the course of a day. This provides the basis for the analysis and simulation of long-term glucose and insulin data. The model may also prove useful for understanding antidiabetic drug actions and requirements in the context of circadian changes in glucose-insulin regulation.
Place, publisher, year, edition, pages
2011. Vol. 51, no 2, 153-164 p.
NONMEM, glucose homeostasis, type 2 diabetes, meal test, circadian rhythm
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-97188DOI: 10.1177/0091270010362536ISI: 000286551600002PubMedID: 20220046OAI: oai:DiVA.org:uu-97188DiVA: diva2:172012