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Chemical and biological integration of a mouldable bioactive ceramic material capable of forming apatite in vivo in teeth
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Technology, Department of Engineering Sciences.
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2004 In: Biomaterials, ISSN 0142-9612, Vol. 25, 2781-2787 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2004. Vol. 25, 2781-2787 p.
URN: urn:nbn:se:uu:diva-97394OAI: oai:DiVA.org:uu-97394DiVA: diva2:172330
Available from: 2008-08-19 Created: 2008-08-19Bibliographically approved
In thesis
1. Calcium-Aluminate as Biomaterial: Synthesis, Design and Evaluation
Open this publication in new window or tab >>Calcium-Aluminate as Biomaterial: Synthesis, Design and Evaluation
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In this thesis different aspects of calcium-aluminate (CA) as biomaterial are presented. Calcium aluminate is a chemically bonded ceramic with inherent properties making it suitable for use as biomaterial in some applications. In this thesis the emphasis is put on the basic chemical, physical and mechanical properties that may be achieved using the CA system as well as synthesis of the CA raw material. The basis for using CA in any application is the synthesis of the raw material. Different synthesis routes for producing CA are presented with focus on high temperature routes and the micro-structural and phase development during synthesis. As a base for further understanding of the CA properties a thorough outline of the reaction chemistry for CA is presented also including a description of how the reactions may be controlled and how formulations can be designed. The surface reactions of CA when subjected to simulated body fluid showed that CA is in vitro bioactive. An in vivo study in teeth also indicates that CA produces apatite at the tooth material interface. Dental materials are subjected to a harsh environment in the mouth with high mechanical forces, erosion and thermal changes. Also the demands on precise handling characteristics are high. For these reasons the in vitro evaluation of physical and mechanical properties are important. In this work several mechanical and physical properties of Ca-based formulations for dental applications has been tested using different methods. Some attention is also put on the specific characteristics of CA and the difficulties that arise when new material classes needs to be tested according to consensus standard methods. Finally studies on a CA-based formulation intended for Vertebroplasty is presented. The studies include basic mechanical properties as well as testing the material in an in vitro model utilising synthetic cancellous bone.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2008. 87 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 452
Calcium-aluminate, Biomaterial, Dental materials, Vertebroplasty, Chemically Bonded Ceramics, Synthesis
National Category
Biomaterials Science
urn:nbn:se:uu:diva-9173 (URN)978-91-554-7248-1 (ISBN)
Public defence
2008-09-12, Siegbahnsalen, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 10:15
Available from: 2008-08-19 Created: 2008-08-19 Last updated: 2011-07-08Bibliographically approved

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