“Space Matters!” claimed Doreen Massey and John Allen at the heart of the Spatial Turn developments (1984). Compensating a four-decades shortfall, this collective volume is the first reader in Byzantine spatial studies. It contextualizes the spatial turn in historical studies by means of interdisciplinary dialogue. An introduction offers an up-to-date state of the art. Twenty-nine case studies provide a wide range of different conceptualizations of space in Byzantine culture articulated in a single collection through a variety of topics and approaches. An afterword frames the future challenges of Byzantine spatial studies in a changing world where space is a claim and a precarious social value.