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On the physical interpretation of the initial bending of a Shapiro-Konopicky-Heckel compression profile
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2009 (English)In: European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, E-ISSN 1873-3441, Vol. 71, no 2, 395-401 p.Article in journal (Refereed) Published
Abstract [en]

The relationship between the natural logarithm of the tablet porosity arc! the applied pressure is used to describe the compression behavior of a powder. Such a relationship, here referred to as a Shapiro-Konopicky-Heckel (SKH) profile, is usually divided into three   regions, of which the first often is non-linear. The objective of this work was to address the question of the mechanisms controlling the compression and the bending of the first region of a SKH profile for dense particles. In this paper, the first region was described by the   Shapiro General Compression Equation, from which a compression parameter was derived as a measure of the bending. The results indicate that for powders undergoing significant particle rearrangement at low applied pressures, the particle rearrangement is the major cause for the initial bending of the SKH profile. For powders showing limited particle rearrangement, the initial bending is mainly caused by the change in particle diameter due to particle fragmentation. It is concluded that the evaluation of the first region of a SKIT profile in terms of bending may be used to assess particle fragmentation. The SKH profile could hence be a useful tool to describe powder compression behavior in terms of particle fragmentation and particle deformation from one single compression analysis.

Place, publisher, year, edition, pages
2009. Vol. 71, no 2, 395-401 p.
Keyword [en]
Powder compression, Heckel, Shapiro, Fragmentation, Powder compression classification system, Powder technology
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-97469DOI: 10.1016/j.ejpb.2008.09.014ISI: 000264045200030PubMedID: 18940252OAI: oai:DiVA.org:uu-97469DiVA: diva2:172430
Available from: 2008-09-09 Created: 2008-09-09 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Compression analysis as a tool for technical characterization and classification of pharmaceutical powders
Open this publication in new window or tab >>Compression analysis as a tool for technical characterization and classification of pharmaceutical powders
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

There are today strong incentives for an increased understanding of material properties and manufacturing processes to facilitate the development of new technologies in the pharmaceutical industry. The purpose of this thesis was to suggest methods requiring a low sample amount for characterization of technical properties of powders.

Compression analysis was used to evaluate the formulation relevance of some compression equations. Using the mechanics of single granules to estimate powder functionality was part of this work. It was concluded that the formability of granular solids and the plasticity of single granules could be determined with compression analysis by using the Kawakita model for single components and binary mixtures of ductile granules.

Further on, the fragmentation propensity of solid particles could be estimated from compression analysis by using the Shapiro equation, enabling indicators of both the fragmentation and the deformation propensity of particles to be derived in one single compression test.

The interpretations of the compression parameters were only valid if the influence of particle rearrangement was negligible for the overall compression profile. An index indicating the extent of particle rearrangement was developed and a classification system of powders into groups dependent on the incidence of particle rearrangement was suggested as tools to enable rational interpretations of compression parameters.

The application of compression analysis was demonstrated by investigating the relevance of the mechanics of granular solids for their tableting abilities. The plasticity of single gran-ules was suggested to influence both the rate of compactibility and the mode of deformation, and consequently the maximal tablet strength. The degree of granule bed deformation was shown to be a potential in line process indicator to describe the tableting forming ability.

This thesis contributes to a scheme, suitable in formulation work and process control, to describe manufacturability of powders for an enhanced tablet formulation technology.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2008. 72 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, ISSN 1651-6192 ; 79
Keyword
compaction, compression, granules, Kawakita, mechanical properties, particles, PAT, pharmaceutical powders, tablets
National Category
Pharmaceutical Sciences
Identifiers
urn:nbn:se:uu:diva-9214 (URN)978-91-554-7265-8 (ISBN)
Public defence
2008-10-03, B21, Biomedical Center, BMC, Husargatan 3, Uppsala, 13:15
Opponent
Supervisors
Available from: 2008-09-09 Created: 2008-09-09Bibliographically approved

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