uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Maximal degree of compression as an indicator of tablet forming abilities for pharmaceutical granules
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmacy.
Manuscript (Other academic)
URN: urn:nbn:se:uu:diva-97471OAI: oai:DiVA.org:uu-97471DiVA: diva2:172432
Available from: 2008-09-09 Created: 2008-09-09 Last updated: 2010-01-13Bibliographically approved
In thesis
1. Compression analysis as a tool for technical characterization and classification of pharmaceutical powders
Open this publication in new window or tab >>Compression analysis as a tool for technical characterization and classification of pharmaceutical powders
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

There are today strong incentives for an increased understanding of material properties and manufacturing processes to facilitate the development of new technologies in the pharmaceutical industry. The purpose of this thesis was to suggest methods requiring a low sample amount for characterization of technical properties of powders.

Compression analysis was used to evaluate the formulation relevance of some compression equations. Using the mechanics of single granules to estimate powder functionality was part of this work. It was concluded that the formability of granular solids and the plasticity of single granules could be determined with compression analysis by using the Kawakita model for single components and binary mixtures of ductile granules.

Further on, the fragmentation propensity of solid particles could be estimated from compression analysis by using the Shapiro equation, enabling indicators of both the fragmentation and the deformation propensity of particles to be derived in one single compression test.

The interpretations of the compression parameters were only valid if the influence of particle rearrangement was negligible for the overall compression profile. An index indicating the extent of particle rearrangement was developed and a classification system of powders into groups dependent on the incidence of particle rearrangement was suggested as tools to enable rational interpretations of compression parameters.

The application of compression analysis was demonstrated by investigating the relevance of the mechanics of granular solids for their tableting abilities. The plasticity of single gran-ules was suggested to influence both the rate of compactibility and the mode of deformation, and consequently the maximal tablet strength. The degree of granule bed deformation was shown to be a potential in line process indicator to describe the tableting forming ability.

This thesis contributes to a scheme, suitable in formulation work and process control, to describe manufacturability of powders for an enhanced tablet formulation technology.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2008. 72 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, ISSN 1651-6192 ; 79
compaction, compression, granules, Kawakita, mechanical properties, particles, PAT, pharmaceutical powders, tablets
National Category
Pharmaceutical Sciences
urn:nbn:se:uu:diva-9214 (URN)978-91-554-7265-8 (ISBN)
Public defence
2008-10-03, B21, Biomedical Center, BMC, Husargatan 3, Uppsala, 13:15
Available from: 2008-09-09 Created: 2008-09-09Bibliographically approved

Open Access in DiVA

No full text

By organisation
Department of Pharmacy

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 179 hits
ReferencesLink to record
Permanent link

Direct link