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Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
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Manuscript (Other academic)
Identifiers
URN: urn:nbn:se:uu:diva-97651OAI: oai:DiVA.org:uu-97651DiVA: diva2:172675
Available from: 2008-10-23 Created: 2008-10-23 Last updated: 2010-01-13Bibliographically approved
In thesis
1. Identification, Characterization and Evolution of Membrane-bound Proteins
Open this publication in new window or tab >>Identification, Characterization and Evolution of Membrane-bound Proteins
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Membrane proteins constitute approximately 30% of all genes in the human genome and two large families of membrane proteins are G protein-coupled receptors (GPCRs) and Solute Carriers (SLCs) with about 800 and 380 human genes, respectively.

In Papers I, II and IV, we report 16 novel human Adhesion GPCRs found by searches in NCBI and Celera databases. In Paper I, we report eight novel human GPCRs, and six in Paper II. We identified two new human Adhesion GPCRs and 17 mouse orthologs in Paper IV. Phylogenetic analysis demonstrates that the 16 novel human genes are additional members of the Adhesion GPCR family and can be divided into eight phylogenetic groups. EST expression charts for the entire repertoire of Adhesions in human and mouse were established, showing widespread distribution in both central and peripheral tissues. Different domains were found in their N-terminus, some, such as pentraxin in GPR112, indicates that they take part in immunological processes.

In Paper III, we discovered seven new human Rhodopsin GPCRs.

In Paper V, we present the identification of two new human genes, termed SLC6A17 and SLC6A18 from the Solute Carriers family 6 (SLC6). We also identified the corresponding orthologs and additional genes from the mouse and rat genomes. We analysed, in total, 430 unique SLC6 proteins from 10 animal, one plant, two fungi and 196 bacterial genomes.

In Paper VI, we provide the first systematic analysis of the evolutionary history of the different SLC families in Eukaryotes. In all, we analysed 2403 sequences in eight species and we delineate the evolutionary history of each of the 46 SLC families.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2008. 61 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 388
Keyword
G protein-coupled receptor, GPCR, Solute Carriers, SLC, Bioinformatics, Evolution, Rhodopsin, Adhesion, Phylogeny
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:uu:diva-9329 (URN)978-91-554-7312-9 (ISBN)
Public defence
2008-11-15, Room B21, BMC, Husargatan 3, Uppsala, 09:00
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Supervisors
Available from: 2008-10-23 Created: 2008-10-23 Last updated: 2013-04-04Bibliographically approved

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