Interplaying factors for the formation of photoswitchable β-hairpins: The advantage of a flexible switch
2009 (English)In: Journal of Peptide Science, ISSN 1075-2617, E-ISSN 1099-1387, Vol. 15, no 2, 107-113 p.Article in journal (Refereed) Published
A series of peptidomimetics intended to promote the β-hairpin motif have been studied. Structural variations include a turn region with and without a photoswitchable chromophore, and strands with amino acid side chains supporting various degrees of interstrand interactions for hairpin stabilisation. The propensity of the compounds to form β-hairpinswas evaluated experimentally by NMR spectroscopy, translational self-diffusion studies and CD spectroscopy. In the presence of hairpin stabilising interstrand interactions, the structurally flexible stilbene chromophore appeared to be well compatible with the imposed secondary structure.
Place, publisher, year, edition, pages
2009. Vol. 15, no 2, 107-113 p.
peptidomemetics, conformational analysis, photoswitches, diffusion coefficients, CD
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-97700DOI: 10.1002/psc.1103ISI: 000262837000008PubMedID: 19090532OAI: oai:DiVA.org:uu-97700DiVA: diva2:172740