Selective Michael-type addition of a D-glucuronic acid derivative in the synthesis of model substances for uronic acid containing polysaccharides
2008 (English)In: Express Polymer Letters, ISSN 1788-618X, Vol. 2, no 8, 553-559 p.Article in journal (Refereed) Published
A flexible protocol for the preparation of model substances for uronic acid containing polysaccharides is presented.We have synthesized a D-glucuronic acid derivative which is designed so that it easily can be conjugated with differentstructures and architectures by selective Michael-type addition. By successful coupling of the glucuronic acidderivative to polyethylene glycol with high degree of conversion, products were obtained that were easily characterized andwhich resembled polysaccharides in terms of solubility and purification methods that could be employed. The model substancecan potentially be used to facilitate optimization of low-degree modification reactions of high molecular weightD-glucuronic acid containing polysaccharides.
Place, publisher, year, edition, pages
2008. Vol. 2, no 8, 553-559 p.
polymer gels, polysaccharides, Michael-type addition, model substance, NMR
IdentifiersURN: urn:nbn:se:uu:diva-97728DOI: 10.3144/expresspolymlett.2008.67ISI: 000263687000004OAI: oai:DiVA.org:uu-97728DiVA: diva2:172778