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Retinal mean transit time in patients with primary open-angle glaucoma and normal-tension glaucoma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
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2007 (English)In: Acta Ophthalmologica Scandinavica, ISSN 1395-3907, E-ISSN 1600-0420, Vol. 85, no 1, 67-72 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To compare the mean transit time (MTT) of retinal circulation in eyes with primary open-angle glaucoma (POAG) and eyes with normal-tension glaucoma (NTG) and examine the possible relationship between MTT and visual field damage, expressed as mean deviation (MD).

Methods: Video fluorescein angiography was performed in 40 patients with POAG or NTG. Dye curves for fluorescein passing through the retinal arteries and veins were used to calculate MTT in each patient with a computer-assisted technique based on an impulse-response analysis (MTTir).

Results: We were able to analyse MTTir in all 40 angiograms. Mean (SD) MTTir was 5.0 (1.5) seconds in eyes with POAG and 4.7 (1.4) seconds in eyes with NTG. The difference was not statistically significant. There was a weak but significant correlation between the MD and MTTir (MTTir = 4.12–0.08*MD; r = −0.49, p = 0.0013).

Conslusions: The results demonstrate that loss of neuronal tissue in glaucoma is combined with an effect on the retinal circulation and that the effect is similar in eyes with NTG and eyes with POAG.

Place, publisher, year, edition, pages
2007. Vol. 85, no 1, 67-72 p.
Keyword [en]
normal-tension glaucoma, primary open-angle glaucoma, retinal blood flow, mean transit time, visual field defects, mean deviation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-97808DOI: 10.1111/j.1600-0420.2006.00780.xISI: 000243634100012PubMedID: 17244213OAI: oai:DiVA.org:uu-97808DiVA: diva2:172886
Available from: 2008-11-20 Created: 2008-11-20 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Analysis of Angiographies in Human Healthy Eyes and in Open-angle Glaucoma: Retinal Mean Transit Time and Optic Nerve Head Circulation
Open this publication in new window or tab >>Analysis of Angiographies in Human Healthy Eyes and in Open-angle Glaucoma: Retinal Mean Transit Time and Optic Nerve Head Circulation
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Purpose of the studies was to develop a more robust technique to determine retinal mean transit time in healthy and in glaucoma eyes and to evaluate the circulation of the optic nerve head in glaucoma patients.

The retinal mean transit time impulse-response method was evaluated in human healthy eyes and normal values and reproducibility were tested.

Fluorescein and indocyanine green angiographies were recorded and the pictures were analyzed to obtain retinal mean transit time and to evaluate the proportion of low-fluorescent pixels of the optic nerve head in the glaucoma patients. Visual field defects were correlated to loss of neuroretinal rim area.

A disturbed circulation was observed in the glaucoma patients, whether primary or secondary to loss of nerve fibre tissue can not be determined from these studies.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2008. 51 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 402
National Category
Ophthalmology
Identifiers
urn:nbn:se:uu:diva-9398 (URN)978-91-554-7347-1 (ISBN)
Public defence
2008-12-13, Enghoffsalen, Ingång 50, 751 85 Akademiska sjukhuset, Uppsala, 13:15
Opponent
Supervisors
Available from: 2008-11-20 Created: 2008-11-20Bibliographically approved

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Bjärnhall, GunillaTomic, LidijaAlm, Albert

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