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On-chip liquid storage and dispensing for lab-on-a-chip applications
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Micro Structural Technology.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Micro Structural Technology.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Micro Structural Technology.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Micro Structural Technology.
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2008 (English)In: Journal of Micromechanics and Microengineering, ISSN 0960-1317, E-ISSN 1361-6439, Vol. 18, no 7, 075036- p.Article in journal (Refereed) Published
Abstract [en]

This work presents novel components for on-chip storage and dispensing inside a lab-on-a-chip (LOC) for applications in immunoassay point-of-care testing (POCT), where incubation and washing steps are essential. It involves easy-to-use on-chip solutions for the sequential thermo-hydraulic actuation of liquids. The novel concept of combining the use of a rubber plug, both as a non-return valve cap and as a liquid injection interface of a sealed reservoir, allows simple filling of a sterilized cavity, as well as the storage and dispensing of reagent and washing buffer liquids. Segmenting the flow with air spacers enables effective rinsing and the use of small volumes of on-chip stored liquids. The chip uses low-resistance resistors as heaters in the paraffin actuator, providing the low-voltage actuation that is preferred for handheld battery driven instruments.

Place, publisher, year, edition, pages
2008. Vol. 18, no 7, 075036- p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-97831DOI: 10.1088/0960-1317/18/7/075036ISI: 000257128100037OAI: oai:DiVA.org:uu-97831DiVA: diva2:172915
Available from: 2008-11-18 Created: 2008-11-18 Last updated: 2017-12-14
In thesis
1. Microactuators for Powerful Pumps
Open this publication in new window or tab >>Microactuators for Powerful Pumps
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

When paraffin wax melts it exhibits a large, relatively incompressible volume expansion. This can be used in microactuators for strong and large displacements, a rare combination among actuators. Furthermore, paraffin is inexpensive, inert and environmentally friendly, as well as easily processed and actuated. Together, these properties give paraffin actuators great potential for use in both low-cost and high-performance applications.

In microfluidics, the miniaturization of various analysis systems decreases the volumes of samples and reagents needed, as well as the analysis throughput time. Using on-chip micropumps increases the efficiency of the microfluidic system, but a challenge for such pumps is the high back-pressure associated with separation, filtration or narrower channels.

The objective of this thesis is to increase the understanding of paraffin in microactuators, as well as to further explore its possibilities and limitations. The main application area has been on-chip micropumps.

For low-cost applications, actuators, pumps and dispensers have been fabricated in plastics and then evaluated. The dispenser is intended for on-chip storage and dispensing of liquids in a lab-on-a-chip that could be used in, e.g., point-of-care testing (POCT).

For high-performance applications, metallic actuators, pumps and dispensers have been accomplished. The micropump is the world’s strongest mechanical micropump in sub-cubic centimetre size, capable of pressures of above 5 MPa. Possible applications are strong microhydraulics, on-chip chromatography, or medical microdosage systems.

A limitation of paraffin is the relatively slow thermal actuation. In this thesis the thermal properties have also been turned into an advantage: Directional solidification is used to accomplish multiple stable states of the actuator displacement, withheld without any power consumption.

For the future, the high-pressure capability may be improved by new designs. Optimization of speed and power consumption can be made by further work on modelling as well as on drive and control of the heating.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2008. 52 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 578
Keyword
µTAS, chromatography, high pressure, lab-on-a-chip, microactuator, microdispenser, micropump, on-chip, paraffin, PCM, point-of-care
National Category
Other Engineering and Technologies
Identifiers
urn:nbn:se:uu:diva-9402 (URN)978-91-554-7352-5 (ISBN)
Public defence
2008-12-12, Ång/2005, Ångströmlaboratoriet, hus 2, Lägerhyddsvägen 1, Uppsala, 09:30
Opponent
Supervisors
Available from: 2008-11-18 Created: 2008-11-18Bibliographically approved

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Bodén, RogerHjort, KlasSchweitz, Jan-Åke

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