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A high-density scan of the Z chromosome in ficedula flycatchers reveals candidate loci for diversifying selection
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
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2010 (English)In: Evolution, ISSN 0014-3820, E-ISSN 1558-5646, Vol. 64, no 12, 3461-3475 p.Article in journal (Refereed) Published
Abstract [en]

Theoretical and empirical data suggest that genes located on sex chromosomes may play an important role both for sexually selected traits and for traits involved in the build-up of hybrid incompatibilities. We investigated patterns of genetic variation in 73 genes located on the Z chromosomes of two species of the flycatcher genus Ficedula, the pied flycatcher and the collared flycatcher. Sequence data were evaluated for signs of selection potentially related to genomic differentiation in these young sister species, which hybridize despite reduced fitness of hybrids. Seven loci were significantly more divergent between the two species than expected under neutrality and they also displayed reduced nucleotide diversity, consistent with having been influenced by directional selection. Two of the detected candidate regions contain genes that are associated with plumage coloration in birds. Plumage characteristics play an important role in species recognition in these flycatchers suggesting that the detected genes may have been involved in the evolution of sexual isolation between the species.

Place, publisher, year, edition, pages
2010. Vol. 64, no 12, 3461-3475 p.
Keyword [en]
FST peak, Nucleotide diversity, Selection, Sex chromosomes, Speciation
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-97944DOI: 10.1111/j.1558-5646.2010.01082.xISI: 000284850100010PubMedID: 20629730OAI: oai:DiVA.org:uu-97944DiVA: diva2:173070
Available from: 2008-12-22 Created: 2008-12-22 Last updated: 2017-12-14
In thesis
1. Gene Mapping in Ficedula Flycatchers
Open this publication in new window or tab >>Gene Mapping in Ficedula Flycatchers
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In order to get full understanding of how evolution proceeds in natural settings it is necessary to reveal the genetic basis of the phenotypic traits that play a role for individual fitness in different environments. There are a few possible approaches, most of which stem from traditional mapping efforts in domestic animals and other model species. Here we set the stage for gene mapping in natural populations of birds by producing a large number of anchor markers of broad utility for avian genetical research and use these markers to generate a genetic map of the collared flycatcher (Ficedula albicollis). The map reveals a very high degree of synteny and gene order conservation between bird species separated by as much as 100 million years. This is encouraging for later stages of mapping procedures in natural populations since this means that there is a possibility to use the information from already characterized avian genomes to track candidate genes for detailed analysis in non-model species. One interesting aspect of the low degree of rearrangements occurring in the avian genomes is that this could play a role in the low rate of hybridization barriers formed in birds compared to for instance mammals. An analysis of Z-linked gene markers reveals relatively long-range linkage disequilibrium (LD) in collared flycatchers compared to other outbred species but still, LD seems to decay within < 50 kb indicating that > 20.000 markers would be needed to cover the genome in an association scan. A detailed scan of 74 Z-linked genes evenly distributed along the chromosome in both the collared flycatcher and the pied flycatcher (Ficedula hypoleuca) indicates that there are regions that evolve under directional selection, regions that might harbor loci of importance for adaptive divergence and/or hybrid inviability.

Place, publisher, year, edition, pages
Uppsala: Universitetsbiblioteket, 2009. 82 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 587Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 587
Keyword
collared flycatcher, SNP, linkage disequilibrium, genetic map, pedigree
Identifiers
urn:nbn:se:uu:diva-9513 (URN)978-91-554-7380-8 (ISBN)
Public defence
2009-01-16, Zootissalen, EBC, Villavägen 9, Uppsala, 09:00
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Supervisors
Available from: 2008-12-22 Created: 2008-12-22 Last updated: 2011-02-24Bibliographically approved

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Backström, NiclasQvarnström, AnnaEllegren, Hans

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