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Niacin response and electrodermal activity in patients with schizophrenia and healthy controls
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
2006 (English)In: Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, Vol. 74, no 5, 339-346 p.Article in journal (Refereed) Published
Abstract [en]

Patients with schizophrenia have in different studies shown reduced niacin sensitivity and lower electrodermal activity (EDA) after auditory stimulation. Peripheral mediation of prostaglandins may have a physiological role in both responses. This motivates study of both niacin response and electrodermal responding in the same patients with schizophrenia. Thirty patients with schizophrenia and 17 controls were investigated with EDA and thereafter given 200mg niacin orally with continuous assessment of skin temperature. The patients showed a delayed temperature increase after niacin ingestion (P=0.002) and a higher frequency of electrodermal non-responding (P<0.05). Response/non-response for niacin correlated with EDA response/non-response in the patient group (P=0.009). The niacin test revealed a slower vasodilation reaction in the patients. The association between response patterns for the niacin test and EDA suggests that a common aberration in skin physiology may be of importance for both reactions in schizophrenia.

Place, publisher, year, edition, pages
2006. Vol. 74, no 5, 339-346 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-97966DOI: 10.1016/j.plefa.2006.02.002PubMedID: 16600583OAI: oai:DiVA.org:uu-97966DiVA: diva2:173101
Available from: 2009-01-01 Created: 2009-01-01 Last updated: 2009-09-28Bibliographically approved
In thesis
1. Physiological Aberrations in Patients with Schizophrenia
Open this publication in new window or tab >>Physiological Aberrations in Patients with Schizophrenia
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In schizophrenia, subtle aberrations in the brain cause functional disturbances like psychotic symptoms and social disability. There are, however, also disturbances outside the CNS indicating a systemic manifestation in the disease. The aim of the present thesis was to gain deeper understanding of the pathophysiological mechanisms underlying schizophrenia with a particular interest in peripheral and systemic manifestations with relevance for the increased risk of obesity and metabolic complications seen in the disease. Therefore, resting energy expenditure (REE), physical capacity, and relevant body composition variables were measured in patients with schizophrenia and in healthy controls. Also niacin skin flush response and electrodermal activity (EDA) were studied.

Patients with schizophrenia exhibited significantly lower REE expressed as kJ/kg, and also lower values compared with predicted levels than the controls. The difference could not be attributed to medication or variations in body composition between the two groups. There was a gender difference with the lowest levels found in male patients.

Male patients exhibited significantly lower physical capacity in terms of predicted maximal oxygen uptake capacity and faster increase in respiratory quotient than male controls.

The oral niacin test revealed a significantly delayed skin flush reaction in patients compared with controls. The patients also exhibited lower EDA response. There was a significant association in response patterns for the niacin and the EDA tests in the patients, but not in controls.

In a test-retest study in patients there was acceptable stability for EDA measures but low test-retest stability for niacin variables. The previously found association in responses for the two tests was, however, replicated.

The results gain support for the concept of schizophrenia as a disease with systemic manifestations including metabolic dysregulation. The findings add to the understanding of the weight gain and the increased risk for cardiovascular morbidity seen in this condition.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2009. 86 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 413
Keyword
Schizophrenia, resting energy expenditure, body composition, physical capacity, oxygen uptake capacity, respiratory quotient, niacin, skin flush reaction, electrodermal activity
National Category
Psychiatry
Identifiers
urn:nbn:se:uu:diva-9521 (URN)978-91-554-7388-4 (ISBN)
Public defence
2009-01-31, Auditorium Minus, Museum Gustavianum, Akademigatan 3, Uppsala, 09:15
Opponent
Supervisors
Available from: 2009-01-01 Created: 2009-01-01 Last updated: 2012-05-09Bibliographically approved

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