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Test-retest stability of the oral niacin test and electrodermal activity in patients with schizophrenia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
2009 (English)In: Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, E-ISSN 1532-2823, Vol. 81, no 5-6, 367-372 p.Article in journal (Refereed) Published
Abstract [en]

In schizophrenia, well-replicated findings support an attenuated niacin skin-flush response. We have previously reported a delayed skin-flush after niacin ingestion and also an association between niacin non-responding and electrodermal non-responding in schizophrenia. The stability of the niacin and electrodermal tests was now studied in a test-retest design. An additional aim was to assess the association previously found. Twenty-three patients with schizophrenia underwent two sessions 3 months apart during which an oral niacin test was conducted and electrodermal activity was measured. Despite similar values for niacin outcome variables at the group level, there was high intraindividual variation. Test-retest stability for the oral niacin test was thus low, although a trend toward correlation for the dichotomous response criterion was found. Most electrodermal measures correlated between baseline and retest. A significant association between the tests was again found; niacin non-responding implied electrodermal non-responding, providing further support for a common underlying aberration in schizophrenia.

Place, publisher, year, edition, pages
2009. Vol. 81, no 5-6, 367-372 p.
Keyword [en]
Electrodermal activity, Niacin, Schizophrenia, Skin-flush, Test-retest stability
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-97967DOI: 10.1016/j.plefa.2009.09.003ISI: 000272903700010PubMedID: 19864122OAI: oai:DiVA.org:uu-97967DiVA: diva2:173102
Available from: 2009-01-01 Created: 2009-01-01 Last updated: 2010-12-20Bibliographically approved
In thesis
1. Physiological Aberrations in Patients with Schizophrenia
Open this publication in new window or tab >>Physiological Aberrations in Patients with Schizophrenia
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In schizophrenia, subtle aberrations in the brain cause functional disturbances like psychotic symptoms and social disability. There are, however, also disturbances outside the CNS indicating a systemic manifestation in the disease. The aim of the present thesis was to gain deeper understanding of the pathophysiological mechanisms underlying schizophrenia with a particular interest in peripheral and systemic manifestations with relevance for the increased risk of obesity and metabolic complications seen in the disease. Therefore, resting energy expenditure (REE), physical capacity, and relevant body composition variables were measured in patients with schizophrenia and in healthy controls. Also niacin skin flush response and electrodermal activity (EDA) were studied.

Patients with schizophrenia exhibited significantly lower REE expressed as kJ/kg, and also lower values compared with predicted levels than the controls. The difference could not be attributed to medication or variations in body composition between the two groups. There was a gender difference with the lowest levels found in male patients.

Male patients exhibited significantly lower physical capacity in terms of predicted maximal oxygen uptake capacity and faster increase in respiratory quotient than male controls.

The oral niacin test revealed a significantly delayed skin flush reaction in patients compared with controls. The patients also exhibited lower EDA response. There was a significant association in response patterns for the niacin and the EDA tests in the patients, but not in controls.

In a test-retest study in patients there was acceptable stability for EDA measures but low test-retest stability for niacin variables. The previously found association in responses for the two tests was, however, replicated.

The results gain support for the concept of schizophrenia as a disease with systemic manifestations including metabolic dysregulation. The findings add to the understanding of the weight gain and the increased risk for cardiovascular morbidity seen in this condition.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2009. 86 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 413
Schizophrenia, resting energy expenditure, body composition, physical capacity, oxygen uptake capacity, respiratory quotient, niacin, skin flush reaction, electrodermal activity
National Category
urn:nbn:se:uu:diva-9521 (URN)978-91-554-7388-4 (ISBN)
Public defence
2009-01-31, Auditorium Minus, Museum Gustavianum, Akademigatan 3, Uppsala, 09:15
Available from: 2009-01-01 Created: 2009-01-01 Last updated: 2012-05-09Bibliographically approved

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