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Impact on dissolution rate of oral solid dosage forms by increasing the temperature and paddle speed with fully automated dissolution robot SingBATH
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2022 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

The pharmaceutical dosage forms usually undergo a test which is intended for assessing in-vitro performance called the dissolution test. Apart from the drug formulation, factors which can affect dissolution rate include revolutions per minute (RPM) of paddle, temperature of the system and cloud point of the excipients. The present study investigated the influence of increase in temperature and RPM of paddle on the dissolution rate of oral solid dosage forms. By using the fully automated dissolution robot SingBATH, the 4 different products were analyzed by applying linear regression model on the dissolution rate of each product in different conditions. Product 1 showed increase in dissolution rate with the increase of RPM at 37°C but dissolution failed to proceed at 47°C temperature. Product 2 indicated increase in dissolution rate with elevated RPM but suppression at 47°C and 57°C temperature. Product 3 and product 4 showed increase in dissolution rate at elevated RPM as well as temperature but there was an exception in product 4 at 57°C and 50 RPM. The experimental results suggest that the temperature and RPM of paddle of dissolution robot SingBATH are considered as promising factors to have an impact on dissolution rate of investigated products. The dissolution rate increases with increasing RPMs which shows the possibility of reduction of experimental time. Moreover, increase in temperature accelerates the dissolution rate in product 3 and product 4 showing the possibility of reduced experimental time. Hence, it is possible to achieve dissolution profiles in less time period by elevating the RPM and where possible, increasing the temperature of the system. 

Place, publisher, year, edition, pages
2022. , p. 25
Keywords [en]
SingBATH, Fully automated dissolution robot, dissolution rate, temperature, RPM of paddle
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-496329OAI: oai:DiVA.org:uu-496329DiVA, id: diva2:1736067
External cooperation
AstraZeneca, Sweden
Subject / course
Pharmacy
Educational program
Master Programme in Drug Discovery and Development
Supervisors
Examiners
Available from: 2023-02-15 Created: 2023-02-10 Last updated: 2025-02-24Bibliographically approved

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CiteExportLink to record
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Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
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More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
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Output format
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  • text
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