The association of maternal chronic hypertension with perinatal death in male and female offspring: a record linkage study of 866,188 women
2008 (English)In: BJOG : an international journal of obstetrics and gynaecology, ISSN 1471-0528, Vol. 115, no 11, 1436-42 p.Article in journal (Refereed) Published
OBJECTIVE: The purpose of this study was to determine whether there is a difference, by gender, in perinatal mortality in chronically hypertensive women compared with normotensive women. DESIGN: Population-based prospective cohort study. SETTING: Sweden. POPULATION: A total of 866,188 women with singleton pregnancies registered in the Swedish Medical Birth Registry 1992-2004, of which 4749 were diagnosed with chronic hypertension. METHODS: Multivariate logistic regression analysis was performed. In a first step, we adjusted for maternal characteristics and in a second step for mild and severe pre-eclampsia, gestational diabetes, placental abruption and small for gestational age. An effect modification by gender was included in the model. MAIN OUTCOME MEASURES: Odds ratios (OR) for intrauterine death, neonatal death and post-neonatal death with respect to gender of offspring. RESULTS: The unadjusted OR of intrauterine death was 4.12 (95% CI: 2.84-5.96) and 1.29 (95% CI: 0.67-2.48) for male and female offspring, respectively, and of neonatal death, it was 3.45 (95% CI: 2.13-5.59) and 2.17 (95% CI: 1.08-4.35) for male and female offspring, respectively. After multivariate analysis, the OR of intrauterine death was 3.07 (95% CI: 2.12-4.46) and neonatal death was 2.99 (95% CI: 1.84-4.85) for male offspring. For female offspring, the OR of intrauterine death was 0.98 (95% CI: 0.51-1.89) and neonatal death was 1.88 (95% CI: 0.93-3.79). CONCLUSION: Mothers with chronic hypertension have an increased risk of perinatal mortality of their male offspring.
Place, publisher, year, edition, pages
2008. Vol. 115, no 11, 1436-42 p.
chronic hypertension, gender, neonatal death, perinatal death; stillbirth
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-98232DOI: 10.1111/j.1471-0528.2008.01844.xISI: 000259223700015PubMedID: 18823491OAI: oai:DiVA.org:uu-98232DiVA: diva2:173903