Brain Vascular Dysfunction in Mothers and Their Children Exposed to PreeclampsiaShow others and affiliations
2023 (English)In: Hypertension, ISSN 0194-911X, E-ISSN 1524-4563, Vol. 80, no 2, p. 242-256Article, review/survey (Refereed) Published
Abstract [en]
Preeclampsia is a maternal syndrome characterized by the new onset of hypertension and proteinuria after 20 weeks of gestation associated with multisystemic complications, including brain alterations. Indeed, brain complications associated with preeclampsia are the leading direct causes of fetal and maternal morbidity and mortality, especially in low- and middle-income countries. In addition to the well-recognized long-term adverse cardiovascular effects of preeclampsia, women who have had preeclampsia have higher risk of stroke, dementia, intracerebral white matter lesions, epilepsy, and perhaps also cognitive decline postpartum. Furthermore, increasing evidence has also associated preeclampsia with similar cognitive and cerebral disorders in the offspring. However, the mechanistic links between these associations remain unresolved. This article summarizes the current knowledge about the cerebrovascular complications elicited by preeclampsia and the potential pathophysiological mechanisms involved, emphasizing the impaired brain vascular function in the mother and their offspring.
Place, publisher, year, edition, pages
American Heart Association , 2023. Vol. 80, no 2, p. 242-256
Keywords [en]
blood-brain barrier, brain, cognition, preeclampsia, pregnancy
National Category
Gynaecology, Obstetrics and Reproductive Medicine Cardiology and Cardiovascular Disease
Identifiers
URN: urn:nbn:se:uu:diva-497168DOI: 10.1161/HYPERTENSIONAHA.122.19408ISI: 000917096300005PubMedID: 35920147OAI: oai:DiVA.org:uu-497168DiVA, id: diva2:1739226
Funder
Swedish Research Council, 2020-01640The Swedish Foundation for International Cooperation in Research and Higher Education (STINT), MG2019-8462The Swedish Brain Foundation, FO2019-01282023-02-242023-02-242025-02-11Bibliographically approved