A mutation in hairless dogs implicates FOXI3 in ectodermal development
2008 (English)In: Science, ISSN 0036-8075, Vol. 321, no 5895, 1462- p.Article in journal (Refereed) Published
Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.
Place, publisher, year, edition, pages
2008. Vol. 321, no 5895, 1462- p.
IdentifiersURN: urn:nbn:se:uu:diva-98245DOI: 10.1126/science.1162525ISI: 000259121800031PubMedID: 18787161OAI: oai:DiVA.org:uu-98245DiVA: diva2:173930