uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
A mutation in hairless dogs implicates FOXI3 in ectodermal development
Show others and affiliations
2008 (English)In: Science, ISSN 0036-8075, Vol. 321, no 5895, 1462- p.Article in journal (Refereed) Published
Abstract [en]

Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.

Place, publisher, year, edition, pages
2008. Vol. 321, no 5895, 1462- p.
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-98245DOI: 10.1126/science.1162525ISI: 000259121800031PubMedID: 18787161OAI: oai:DiVA.org:uu-98245DiVA: diva2:173930
Available from: 2009-02-18 Created: 2009-02-18 Last updated: 2011-06-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lindblad-Toh, Kerstin
By organisation
Department of Medical Biochemistry and Microbiology
In the same journal
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 310 hits
ReferencesLink to record
Permanent link

Direct link